Gene

pou1f1

ID

ZDB-GENE-040630-7

Name

POU class 1 homeobox 1

Symbol

pou1f1 Nomenclature History

Previous Names

pit-1 (1)
Pit1 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate specification. Predicted to be located in nucleus. Is expressed in adenohypophyseal placode; adenohypophysis; brain; head; and hypophysis. Human ortholog(s) of this gene implicated in combined or isolated pituitary hormone deficiency 1 and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 20 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu451 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Phenotype Annotation (1994-2006)
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pou1f1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined or isolated pituitary hormone deficiency 1	Alliance	Pituitary hormone deficiency, combined or isolated, 1	613038

Associated With pou1f1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR000327	POU-specific domain
Domain	IPR001356	Homeodomain
Domain	IPR013847	POU domain
Family	IPR050255	POU domain transcription factor
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily