Gene
tnnc1b
- ID
- ZDB-GENE-040625-62
- Name
- troponin C type 1b (slow)
- Symbol
- tnnc1b Nomenclature History
- Previous Names
-
- stnnc
- ssTnC (1)
- zgc:86932
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and troponin I binding activity. Acts upstream of or within cardiac muscle contraction. Predicted to be part of cardiac Troponin complex. Is expressed in adaxial cell; heart; musculature system; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6899234 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa29906 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1Z | Alliance | Cardiomyopathy, dilated, 1Z | 611879 |
| hypertrophic cardiomyopathy 13 | Alliance | Cardiomyopathy, hypertrophic, 13 | 613243 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calmodulin/Myosin light chain/Troponin C-like | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|---|
| UniProtKB:Q6IQ64 | InterPro | 161 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnnc1b-201
(1)
|
Ensembl | 874 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.5tnnc1b:EGFP) |
|
| 1 | (2) | |
| Tg(-2.5tnnc1b:EGFP-tnnc1b) |
|
|
| 1 | (2) |
| Tg(-.270tnnc1b:EGFP-tnnc1b) |
|
|
| 1 | (2) |
| TgBAC(tnnc1b:EGFP-tnnc1b) |
|
|
| 1 | (2) |
| Tg(tnnc1b:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-32E6 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6899234 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86932 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002085 (1) | 811 nt | ||
| Genomic | GenBank:AL953864 (1) | 249608 nt | ||
| Polypeptide | UniProtKB:Q6IQ64 (1) | 161 aa |
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Zhou, C., Zhao, W., Zhang, S., Ma, J., Sultan, Y., Li, X. (2022) High-throughput transcriptome sequencing reveals the key stages of cardiovascular development in zebrafish embryos. BMC Genomics. 23:587
- Li, S., Wen, H., Du, S. (2020) Defective sarcomere organization and reduced larval locomotion and fish survival in slow muscle heavy chain 1 (smyhc1) mutants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:1378-1397
- Goldman, J.A., Kuzu, G., Lee, N., Karasik, J., Gemberling, M., Foglia, M.J., Karra, R., Dickson, A.L., Sun, F., Tolstorukov, M.Y., Poss, K.D. (2017) Resolving Heart Regeneration by Replacement Histone Profiling. Developmental Cell. 40:392-404.e5
- Genge, C.E., Stevens, C.M., Davidson, W.S., Singh, G., Tieleman, D.P., Tibbits, G.F. (2016) Functional divergence in teleost cardiac troponin paralogs guides variation in the interaction of TnI switch region with TnC. Genome biology and evolution. 8(4):994-1011
- Gomes, R.S., Skroblin, P., Munster, A.B., Tomlins, H., Langley, S.R., Zampetaki, A., Yin, X., Wardle, F., Mayr, M. (2016) "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Journal of Molecular and Cellular Cardiology. 92:105-8
- Orr, N., Arnaout, R., Gula, L.J., Spears, D.A., Leong-Sit, P., Li, Q., Tarhuni, W., Reischauer, S., Chauhan, V.S., Borkovich, M., Uppal, S., Adler, A., Coughlin, S.R., Stainier, D.Y., Gollob, M.H. (2016) A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nature communications. 7:11303
- Singh, A.R., Sivadas, A., Sabharwal, A., Vellarikal, S.K., Jayarajan, R., Verma, A., Kapoor, S., Joshi, A., Scaria, V., Sivasubbu, S. (2016) Chamber Specific Gene Expression Landscape of the Zebrafish Heart. PLoS One. 11:e0147823
- Stevens, C.M., Rayani, K., Genge, C.E., Singh, G., Liang, B., Roller, J.M., Li, C., Li, A.Y., Tieleman, D.P., van Petegem, F., Tibbits, G.F. (2016) Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC. Biophysical journal. 111:38-49
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