Gene
sae1
- ID
- ZDB-GENE-040625-21
- Name
- SUMO1 activating enzyme subunit 1
- Symbol
- sae1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable SUMO activating enzyme activity. Acts upstream of or within definitive hemopoiesis; hematopoietic stem cell homeostasis; and protein sumoylation. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in brain. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910490 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hkz5 | Allele with one point mutation | Exon 7 | Premature Stop | ENU | |
| la019246Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019247Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22643 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ThiF/MoeB/HesA family | THIF-type NAD/FAD binding fold | Ubiquitin/SUMO-activating enzyme E1-like |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q099 | InterPro | 309 | |||
| UniProtKB:Q6IQS6 | InterPro | 348 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31M14 | ZFIN Curated Data | |
| Encodes | EST | fa28b04 | ||
| Encodes | EST | IMAGE:6910490 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86633 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002058 (1) | 1495 nt | ||
| Genomic | GenBank:CR855332 (1) | 212455 nt | ||
| Polypeptide | UniProtKB:Q6IQS6 (1) | 348 aa |
- Liu, S., Hu, G., Luo, S., Wu, W., Zhou, Q., Jin, R., Zhang, Y., Ruan, H., Huang, H., Li, H. (2022) Insights into the evolution of the ISG15 and UBA7 system. Genomics. 114(2):110302
- Pagano, C., di Martino, O., Ruggiero, G., Guarino, A.M., Mueller, N., Siauciunaite, R., Reischl, M., Foulkes, N.S., Vallone, D., Calabrò, V. (2017) The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation. Oncotarget. 8(4):6193-6205
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yuan, H., Zhang, T., Liu, X., Deng, M., Zhang, W., Wen, Z., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2015) Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Scientific Reports. 5:9011
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Li, X., Lan, Y., Xu, J., Zhang, W., and Wen, Z. (2012) SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Development (Cambridge, England). 139(23):4321-4329
- Zhang, P., Lu, L., Yao, Q., Li, Y., Zhou, J., Liu, Y., and Duan, C. (2012) Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α. American journal of physiology. Regulatory, integrative and comparative physiology. 303(11):R1165-R1174
- Amaral, I.P., and Johnston, I.A. (2011) Insulin-like growth factor (IGF) signalling and genome-wide transcriptional regulation in fast muscle of zebrafish following a single-satiating meal. The Journal of experimental biology. 214(13):2125-2139
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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