Gene
cyp51
- ID
- ZDB-GENE-040625-2
- Name
- cytochrome P450, family 51
- Symbol
- cyp51 Nomenclature History
- Previous Names
-
- wu:fb66a09
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables sterol 14-demethylase activity. Acts upstream of or within response to yeast. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including epidermis; head; liver; pleuroperitoneal region; and primordial germ cell. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group IV | Cytochrome P450, sterol 14-alpha demethylase | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q1JPY5 | InterPro | 499 | |||||
| UniProtKB:A0AB32T5R1 | InterPro | 498 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(Cca.Actb1:cyp51-GFP) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(Cca.Actb:cyp51-GFP) |
|
| 2 | Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-440P11 | ZFIN Curated Data | |
| Encodes | EST | fb66a09 | ||
| Encodes | cDNA | MGC:136479 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191208 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001730 (1) | 2445 nt | ||
| Genomic | GenBank:CU638710 (2) | 39223 nt | ||
| Polypeptide | UniProtKB:Q1JPY5 (1) | 499 aa |
- Xu, H., Cao, L., Chen, Y., Zhou, C., Xu, J., Zhang, Z., Li, X., Liu, L., Lu, J. (2024) Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration. Neural regeneration research. :
- Guirgis, F.W., Jacob, V., Wu, D., Henson, M., Daly-Crews, K., Hopson, C., Black, L.P., DeVos, E.L., Sulaiman, D., Labilloy, G., Brusko, T.M., Shavit, J.A., Bertrand, A., Feldhammer, M., Baskovich, B., Graim, K., Datta, S., Reddy, S.T. (2023) DHCR7 Expression Predicts Porsusor Outcomes and Mortality From Sepsis. Critical care explorations. 5:e0929e0929
- Zhai, W., Wang, Z., Ye, C., Ke, L., Wang, H., Liu, H. (2023) IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas hydrophila Infection by Reducing Oxidative Stress in Zebrafish. International Journal of Molecular Sciences. 24(24):
- Osorio-Méndez, D., Miller, A., Begeman, I.J., Kurth, A., Hagle, R., Rolph, D., Dickson, A.L., Chen, C.H., Halloran, M., Poss, K.D., Kang, J. (2022) Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins. Proceedings of the National Academy of Sciences of the United States of America. 119:e2200342119
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li, M. (2022) Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Frontiers in endocrinology. 13:864631
- Gourain, V., Armant, O., Lübke, L., Diotel, N., Rastegar, S., Strähle, U. (2021) Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury. Frontiers in neuroscience. 15:671249
- Li, N., Gao, S., Wang, S., He, S., Wang, J., He, L., Jiang, D., Shi, Y.S., Zhang, J., Gu, Y., Chen, T., Kong, M., Xu, X., Zhao, Q. (2021) Attractin Participates in Schizophrenia by Affecting Testosterone Levels. Frontiers in cell and developmental biology. 9:755165
- Limonta, G., Mancia, A., Abelli, L., Fossi, M.C., Caliani, I., Panti, C. (2021) Effects of microplastics on head kidney gene expression and enzymatic biomarkers in adult zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 245:109037
- Novak, M., Baebler, Š., Žegura, B., Rotter, A., Gajski, G., Gerić, M., Garaj-Vrhovac, V., Bakos, K., Csenki, Z., Kovács, R., Horváth, Á., Gazsi, G., Filipič, M. (2021) Deregulation of whole-transcriptome gene expression in zebrafish (Danio rerio) after chronic exposure to low doses of imatinib mesylate in a complete life cycle study. Chemosphere. 263:128097
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