Gene
tnni2a.4
- ID
- ZDB-GENE-040625-119
- Name
- troponin I type 2a (skeletal, fast), tandem duplicate 4
- Symbol
- tnni2a.4 Nomenclature History
- Previous Names
-
- tnni2
- TnnI2
- tropI-1d (1)
- hm:zehn0173
- zgc:86800
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity. Acts upstream of or within myofibril assembly. Predicted to be part of troponin complex. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907617 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 2B1 | Alliance | Arthrogryposis, distal, type 2B1 | 601680 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Troponin | Troponin domain superfamily | Troponin I |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BA47 | InterPro | 178 | |||
| UniProtKB:Q0D2W2 | InterPro | 176 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnni2a.4-201
(1)
|
Ensembl | 764 nt | ||
| mRNA |
tnni2a.4-202
(1)
|
Ensembl | 1,331 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-9F16 | ZFIN Curated Data | |
| Contained in | BAC | RP71-8I12 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6907617 | Thisse et al., 2004 | |
| Encodes | EST | zehn0173 | ||
| Encodes | cDNA | MGC:86800 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193805 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193817 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009901 (1) | 831 nt | ||
| Genomic | GenBank:CU302206 (2) | 53614 nt | ||
| Polypeptide | UniProtKB:A0A8M2BA47 (1) | 178 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- tnni2a.1, tnni2a.2, tnni2a.3, and tnni2a.4 form a cluster on chromosome 25 and are likely the result of tandem duplications. The location of the cluster in zebrafish as well as the amino acid identity of all genes in the cluster support orthology to human TNNI2 and mouse Tnni2.
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Hayes, M.N., McCarthy, K., Jin, A., Oliveira, M.L., Iyer, S., Garcia, S.P., Sindiri, S., Gryder, B., Motala, Z., Nielsen, G.P., Borg, J.P., van de Rijn, M., Malkin, D., Khan, J., Ignatius, M.S., Langenau, D.M. (2018) Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma. Cell Stem Cell. 22:414-427.e6
- Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652
- Xu, Q.H., Guan, P., Zhang, T., Lu, C., Li, G., Liu, J.X. (2018) Silver nanoparticles impair zebrafish skeletal and cardiac myofibrillogenesis and sarcomere formation. Aquatic toxicology (Amsterdam, Netherlands). 200:102-113
- Wen, Y., Ushio, H. (2017) Ferulic Acid Promotes Hypertrophic Growth of Fast Skeletal Muscle in Zebrafish Model. Nutrients. 9(10)
- Genge, C.E., Stevens, C.M., Davidson, W.S., Singh, G., Tieleman, D.P., Tibbits, G.F. (2016) Functional divergence in teleost cardiac troponin paralogs guides variation in the interaction of TnI switch region with TnC. Genome biology and evolution. 8(4):994-1011
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9
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