Gene
zic5
- ID
- ZDB-GENE-040622-1
- Name
- Zic family zinc finger 5
- Symbol
- zic5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within nervous system development; regulation of cell population proliferation; and regulation of neurogenesis. Predicted to be active in nucleus. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; central nervous system; lateral plate mesoderm; neural plate; and optic vesicle. Orthologous to human ZIC5 (Zic family member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu548 (24 images)
- IMAGE:7157050 (41 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010776Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026900Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-zic5 | N/A | (2) |
| MO2-zic5 | N/A | Coolen et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2H2-type zinc-finger protein GLI-like | ZIC1-5/GLI1-3like, C2H2 zinc finger | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6VUB8 | InterPro | 497 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-277G23 | ZFIN Curated Data | |
| Encodes | EST | eu548 | Thisse et al., 2005 | |
| Encodes | EST | IMAGE:7157050 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:193830 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193860 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205727 (1) | 2599 nt | ||
| Genomic | GenBank:BX469902 (1) | 179135 nt | ||
| Polypeptide | UniProtKB:Q6VUB8 (1) | 497 aa |
- Zhang, Q., Li, T., Zhang, Y., Lin, J., Chen, X., Gui, Y., Li, Q. (2020) Comparative sequence analysis and functional validation identified a retina-specific enhancer around zic5 and zic2a. Gene expression patterns : GEP. 39:119162
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Sedykh, I., Keller, A.N., Yoon, B., Roberson, L., Moskvin, O.V., Grinblat, Y. (2017) Zebrafish Rfx4 controls dorsal and ventral midline formation in the neural tube. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(4):650-659
- Chen, Y.C., Semenova, S., Rozov, S., Sundvik, M., Bonkowsky, J.L., Panula, P. (2016) A novel developmental role for dopaminergic signaling to specify hypothalamic neurotransmitter identity. The Journal of biological chemistry. 291(42):21880-21892
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
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