Gene
esrrb
- ID
- ZDB-GENE-040616-2
- Name
- estrogen-related receptor beta
- Symbol
- esrrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable estrogen response element binding activity and nuclear receptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Is expressed in basal plate midbrain region; nervous system; and pronephric duct. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- ay556396 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 35 | Alliance | Deafness, autosomal recessive 35 | 608565 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
| Family | IPR027289 | Oestrogen-related receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Oestrogen-related receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P2J7 | InterPro | 437 | ||||||||
| UniProtKB:Q6Q6F5 | InterPro | 340 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001324539 (1) | 2426 nt | ||
| Genomic | GenBank:CABZ01113871 (1) | 43347 nt | ||
| Polypeptide | UniProtKB:A0A8M1P2J7 (1) | 437 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Iglesias González, A.B., Jakobsson, J.E.T., Vieillard, J., Lagerström, M.C., Kullander, K., Boije, H. (2021) Single Cell Transcriptomic Analysis of Spinal Dmrt3 Neurons in Zebrafish and Mouse Identifies Distinct Subtypes and Reveal Novel Subpopulations Within the dI6 Domain. Frontiers in Cellular Neuroscience. 15:781197
- Geronikolou, S.A., Pavlopoulou, A., Kanaka-Gantenbein, C., Chrousos, G. (2018) Inter-species functional interactome of nuclear steroid receptors (R1). Frontiers in bioscience (Elite edition). 10:208-228
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Sugano, Y., Cianciolo Cosentino, C., Loffing-Cueni, D., Neuhauss, S.C.F., Loffing, J. (2017) Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule. Pflugers Archiv : European journal of physiology. 469(7-8):859-867
- Kim, Y.I., No Lee, J., Bhandari, S., Nam, I.K., Yoo, K.W., Kim, S.J., Oh, G.S., Kim, H.J., So, H.S., Choe, S.K., Park, R. (2015) Cartilage development requires the function of Estrogen-related receptor alpha that directly regulates sox9 expression in zebrafish. Scientific Reports. 5:18011
- Liu, C., Song, G., Mao, L., Long, Y., Li, Q., Cui, Z. (2015) Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish. PLoS One. 10:e0139612
- Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554
- Smith, R.P., Riesenfeld, S.J., Holloway, A.K., Li, Q., Murphy, K.K., Feliciano, N.M., Orecchia, L., Oksenberg, N., Pollard, K.S., and Ahituv, N. (2013) A compact, in vivo screen of all 6-mers reveals drivers of tissue-specific expression and guides synthetic regulatory element design. Genome biology. 14(7):R72
- Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188
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