Gene
nrp2a
- ID
- ZDB-GENE-040611-2
- Name
- neuropilin 2a
- Symbol
- nrp2a Nomenclature History
- Previous Names
-
- npn-2A (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within neural crest cell migration; regulation of vascular endothelial growth factor receptor signaling pathway; and vasculogenesis. Predicted to be located in membrane. Predicted to be active in axon; glutamatergic synapse; and postsynaptic membrane. Is expressed in axial vasculature; bulbus arteriosus; cranial neural crest cell; fin bud; and nervous system. Orthologous to human NRP2 (neuropilin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hermans et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021215Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13255 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13721 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25512 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32581 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3896 | Allele with one insertion | Exon 2 | Unknown | CRISPR | |
| zko100a | Allele with one delins | Unknown | Unknown | CRISPR | |
| zko100b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nrp2a | (2) | |
| CRISPR2-nrp2a | van der Klaauw et al., 2019 | |
| CRISPR3-nrp2a | van der Klaauw et al., 2019 | |
| CRISPR4-nrp2a | van der Klaauw et al., 2019 | |
| CRISPR5-nrp2a | van der Klaauw et al., 2019 | |
| CRISPR6-nrp2a | Cheng et al., 2022 | |
| MO1-nrp2a | N/A | (3) |
| MO2-nrp2a | N/A | (3) |
| MO3-nrp2a | N/A | (2) |
| MO4-nrp2a | N/A | Martyn et al., 2004 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor 5/8, C-terminal domain | Concanavalin A-like lectin/glucanase domain superfamily | CUB domain | Galactose-binding-like domain superfamily | MAM domain | Neuropilin | Neuropilin, C-terminal | Neuropilin/Multicopper Oxidase/Coagulation Factor | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P3S9 | InterPro | 902 | |||||||||
| UniProtKB:Q6T868 | InterPro | 927 | |||||||||
| UniProtKB:A0AB32TE49 | InterPro | 916 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-76B22 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-331F6 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-435A3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193601 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212965 (1) | 5316 nt | ||
| Genomic | GenBank:CU469569 (2) | 102276 nt | ||
| Polypeptide | UniProtKB:Q6T868 (1) | 927 aa |
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Cheng, R.P., Dang, P., Taku, A.A., Moon, Y.J., Pham, V., Sun, X., Zhao, E., Raper, J.A. (2022) Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting. Neural Development. 17:1
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
- Halabi, R., Watterston, C., Hehr, C.L., Mori-Kreiner, R., Childs, S.J., McFarlane, S. (2021) Semaphorin 3fa Controls Ocular Vascularization From the Embryo Through to the Adult. Investigative ophthalmology & visual science. 62:21
- Li, G.X., Zhang, S., Liu, R., Singh, B., Singh, S., Quinn, D.I., Crump, G., Gill, P.S. (2020) Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 10(2):
- Weinberger, M., Simões, F.C., Patient, R., Sauka-Spengler, T., Riley, P.R. (2020) Functional Heterogeneity within the Developing Zebrafish Epicardium. Developmental Cell. 52(5):574-590.e6
- Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I.C., Pellet-Many, C. (2019) Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development (Cambridge, England). 146(13):
- Mullapudi, S.T., Boezio, G.L.M., Rossi, A., Marass, M., Matsuoka, R.L., Matsuda, H., Helker, C.S.M., Yang, Y.H.C., Stainier, D.Y.R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development (Cambridge, England). 146(21):
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
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