Gene

nrp1b

ID
ZDB-GENE-040611-1
Name
neuropilin 1b
Symbol
nrp1b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable semaphorin receptor activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and positive regulation of filopodium assembly. Acts upstream of or within several processes, including regulation of vascular endothelial growth factor receptor signaling pathway; response to hypoxia; and vasculature development. Predicted to be located in membrane. Predicted to be active in axon; focal adhesion; and plasma membrane. Is expressed in cranial neural crest cell; mid cerebral vein; retinal ganglion cell layer; somite; and trunk vasculature. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
fh278Allele with one point mutationUnknownPremature StopENU
fh279Allele with one point mutationUnknownUnknownENU
la028822TgTransgenic insertionUnknownUnknownDNA
nrp1b_unrecoveredAllele with one point mutationUnknownUnknownENU
sa9247Allele with one point mutationUnknownPremature StopENU
sa19852Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With nrp1b Human Ortholog
No data available
Associated With nrp1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000421 Coagulation factor 5/8, C-terminal domain
Domain IPR000859 CUB domain
Domain IPR000998 MAM domain
Domain IPR022579 Neuropilin, C-terminal
Family IPR014648 Neuropilin
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Domain Details Per Protein
Protein Additional Resources Length Coagulation factor 5/8, C-terminal domain Concanavalin A-like lectin/glucanase domain superfamily CUB domain Galactose-binding-like domain superfamily MAM domain Neuropilin Neuropilin, C-terminal Neuropilin/Multicopper Oxidase/Coagulation Factor Spermadhesin, CUB domain superfamily
UniProtKB:Q6T870 InterPro 959
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nrp1b-201 (1) Ensembl 2,026 nt
mRNA nrp1b-202 (1) Ensembl 1,387 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-218A22ZFIN Curated Data
EncodescDNAMGC:158182ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanNRP110
Conserved genome location (synteny) (1)
Amino acid sequence comparison (3)
MouseNrp18
Amino acid sequence comparison (1)
Citations
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