Gene
nrp1b
- ID
- ZDB-GENE-040611-1
- Name
- neuropilin 1b
- Symbol
- nrp1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable semaphorin receptor activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and positive regulation of filopodium assembly. Acts upstream of or within several processes, including regulation of vascular endothelial growth factor receptor signaling pathway; response to hypoxia; and vasculature development. Predicted to be located in membrane. Predicted to be active in axon; focal adhesion; and plasma membrane. Is expressed in cranial neural crest cell; mid cerebral vein; retinal ganglion cell layer; somite; and trunk vasculature. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
fh278 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
fh279 | Allele with one point mutation | Unknown | Unknown | ENU | |
la028822Tg | Transgenic insertion | Unknown | Unknown | DNA | |
nrp1b_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
sa9247 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19852 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Coagulation factor 5/8, C-terminal domain | Concanavalin A-like lectin/glucanase domain superfamily | CUB domain | Galactose-binding-like domain superfamily | MAM domain | Neuropilin | Neuropilin, C-terminal | Neuropilin/Multicopper Oxidase/Coagulation Factor | Spermadhesin, CUB domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6T870 | InterPro | 959 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-218A22 | ZFIN Curated Data | |
Encodes | cDNA | MGC:158182 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_205674 (1) | 4633 nt | ||
Genomic | GenBank:BX088727 (2) | 185178 nt | ||
Polypeptide | UniProtKB:Q6T870 (1) | 959 aa |
- Singh Angom, R., Wang, Y., Wang, E., Dutta, S., Mukhopadhyay, D. (2023) Conditional, Tissue-Specific CRISPR/Cas9 Vector System in Zebrafish Reveals the Role of Nrp1b in Heart Regeneration. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(10):1921-1934
- Li, G.X., Zhang, S., Liu, R., Singh, B., Singh, S., Quinn, D.I., Crump, G., Gill, P.S. (2020) Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 10(2):
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I.C., Pellet-Many, C. (2019) Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development (Cambridge, England). 146(13):
- Mullapudi, S.T., Boezio, G.L.M., Rossi, A., Marass, M., Matsuoka, R.L., Matsuda, H., Helker, C.S.M., Yang, Y.H.C., Stainier, D.Y.R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development (Cambridge, England). 146(21):
- van der Klaauw, A.A., Croizier, S., Mendes de Oliveira, E., Stadler, L.K.J., Park, S., Kong, Y., Banton, M.C., Tandon, P., Hendricks, A.E., Keogh, J.M., Riley, S.E., Papadia, S., Henning, E., Bounds, R., Bochukova, E.G., Mistry, V., O'Rahilly, S., Simerly, R.B., INTERVAL, UK10K Consortium, Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G., Farooqi, I.S. (2019) Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 176(4):729-742.e18
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Dang, P., Fisher, S.A., Stefanik, D., Kim, J., Raper, J.A. (2018) Coordination of olfactory receptor choice with guidance receptor expression and function in olfactory sensory neurons. PLoS Genetics. 14:e1007164
- Tao, B., Hu, H., Mitchell, K., Chen, J., Jia, H., Zhu, Z., Trudeau, V.L., Hu, W. (2018) Secretogranin-II plays a critical role in zebrafish neurovascular modeling. Journal of molecular cell biology. 10(5):388-401
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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