Gene
nr1d2a
- ID
- ZDB-GENE-040504-1
- Name
- nuclear receptor subfamily 1, group D, member 2a
- Symbol
- nr1d2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of or within circadian regulation of gene expression and regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in nervous system. Orthologous to human NR1D2 (nuclear receptor subfamily 1 group D member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- af342941 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18069 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR001728 | Thyroid hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QIC9 | InterPro | 504 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nr1d2a-201
(1)
|
Ensembl | 3,081 nt | ||
| mRNA |
nr1d2a-203
(1)
|
Ensembl | 3,995 nt | ||
| ncRNA |
nr1d2a-002
(1)
|
Ensembl | 450 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-231M23 | ZFIN Curated Data | |
| Encodes | EST | af342941 | Bertrand et al., 2007 | |
| Encodes | cDNA | MGC:194318 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130592 (1) | 3995 nt | ||
| Genomic | GenBank:CU855686 (1) | 137702 nt | ||
| Polypeptide | UniProtKB:F1QIC9 (1) | 504 aa |
- He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929
- Wu, J., Lin, X., Wu, D., Yan, B., Bao, M., Zheng, P., Wang, J., Yang, C., Li, Z., Jin, X., Jiang, K. (2023) Poly(I:C)-exposed zebrafish shows autism-like behaviors which are ameliorated by fabp2 gene knockout. Frontiers in molecular neuroscience. 15:10680191068019
- Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109
- Zheng, X., Zhang, K., Zhao, Y., Fent, K. (2021) Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans. Environment International. 149:106159
- Jaikumar, G., Slabbekoorn, H., Sireeni, J., Schaaf, M., Tudorache, C. (2020) The role of the Glucocorticoid Receptor in the Regulation of Diel Rhythmicity. Physiology & behavior. 223:112991
- Faltermann, S., Hettich, T., Küng, N., Fent, K. (2019) Effects of the glucocorticoid clobetasol propionate and its mixture with cortisol and different class steroids in adult female zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 218:105372
- Liang, Y.Q., Huang, G.Y., Zhen, Z., Tian, F., Hou, L., Lin, Z., Ying, G.G. (2019) The effects of binary mixtures of estradiol and progesterone on transcriptional expression profiles of genes involved in hypothalamic-pituitary-gonadal axis and circadian rhythm signaling in embryonic zebrafish (Danio rerio). Ecotoxicology and environmental safety. 174:540-548
- Schmid, S., Willi, R.A., Salgueiro-González, N., Fent, K. (2019) Effects of new generation progestins, including as mixtures and in combination with other classes of steroid hormones, on zebrafish early life stages. The Science of the total environment. 709:136262
- Willi, R., Castiglioni, S., Salgueiro Gonzalez, N., Furia, N., Mastroianni, S., Faltermann, S., Fent, K. (2019) Physiological and transcriptional effects of mixtures of environmental estrogens, androgens, progestins and glucocorticoids in zebrafish. Environmental science & technology. 54(2):1092-1101
- Willi, R.A., Salgueiro-González, N., Faltermann, S., Hettich, T., Fent, K. (2019) Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. The Science of the total environment. 672:183-191
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