Gene

egfl7

ID
ZDB-GENE-040429-2
Name
EGF-like-domain, multiple 7
Symbol
egfl7 Nomenclature History
Previous Names
  • zgc:136669
  • zgc:152804
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable signaling receptor binding activity. Acts upstream of or within vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in caudal vein plexus. Orthologous to several human genes including EGFL7 (EGF like domain multiple 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
bns302Allele with one deletionUnknownUnknownCRISPR
bns303Allele with one deletionExon 1UnknownCRISPR
s980Allele with one deletionExon 3Inframe DeletionTALEN
s981Allele with one delinsExon 3Frameshift, Premature StopTALEN
cq180Allele with one deletionExon 3UnknownCRISPR
la012023TgTransgenic insertionUnknownUnknownDNA
nkgsaizGFFD478AGtTransgenic insertionUnknownUnknownDNA
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Sequence Targeting Reagents
Human Disease
Associated With egfl7 Human Ortholog
No data available
Associated With egfl7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR011489 EMI domain
Domain IPR049883 NOTCH1 EGF-like calcium-binding domain
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Domain Details Per Protein
Protein Additional Resources Length Developmental Signaling Modulators EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site EMI domain NOTCH1 EGF-like calcium-binding domain
UniProtKB:Q1RLZ3 InterPro 277
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 21
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA egfl7-201 (1) Ensembl 1,331 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(egfl7:YFP)
  • egfl7
  • Danio rerio
1Chen et al., 2024
Tg(kdrl:egfl7-2A-GFP)
  • Danio rerio
1Chen et al., 2024
Tg(lyve1b:egfl7-2A-GFP)
  • Danio rerio
1Chen et al., 2024
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-390O6ZFIN Curated Data
EncodescDNAMGC:136669ZFIN Curated Data
EncodescDNAMGC:152804ZFIN Curated Data
EncodescDNAMGC:193537ZFIN Curated Data
EncodescDNAMGC:193539ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanEGFL79
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseEgfl72
Amino acid sequence comparison (1)
Citations
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