Gene
egfl7
- ID
- ZDB-GENE-040429-2
- Name
- EGF-like-domain, multiple 7
- Symbol
- egfl7 Nomenclature History
- Previous Names
-
- zgc:136669
- zgc:152804
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in caudal vein plexus. Orthologous to several human genes including EGFL7 (EGF like domain multiple 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns302 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns303 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| s980 | Allele with one deletion | Exon 3 | Inframe Deletion | TALEN | |
| s981 | Allele with one delins | Exon 3 | Frameshift, Premature Stop | TALEN | |
| cq180 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| la012023Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nkgsaizGFFD478AGt | Transgenic insertion | Unknown | Unknown | DNA |
1 - 7 of 7
Show
1 - 10 of 13
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Developmental Signaling Modulators | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | EMI domain | NOTCH1 EGF-like calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1RLZ3 | InterPro | 277 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(egfl7:YFP) |
|
| 1 | Chen et al., 2024 | |
| Tg(kdrl:egfl7-2A-GFP) |
| 1 | Chen et al., 2024 | ||
| Tg(lyve1b:egfl7-2A-GFP) |
| 1 | Chen et al., 2024 |
1 - 3 of 3
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-390O6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136669 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152804 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193537 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193539 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040385 (1) | 1438 nt | ||
| Genomic | GenBank:CU929160 (2) | 105650 nt | ||
| Polypeptide | UniProtKB:Q1RLZ3 (1) | 277 aa |
- Chen, J., Ding, J., Li, Y., Feng, F., Xu, Y., Wang, T., He, J., Cang, J., Luo, L. (2024) Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3. Nature communications. 15:59865986
- Edwards, H.E., Edgington, M.J., Souder, J.P., Gorelick, D.A. (2023) Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos. Development (Cambridge, England). 150(9)
- Han, B., Zhang, Y., Zhou, Y., Zhang, B., Krueger, C.J., Bi, X., Zhu, Z., Tong, X., Zhang, B. (2022) ErCas12a and T5exo-ErCas12a Mediate Simple and Efficient Genome Editing in Zebrafish. Biology. 11(3):
- Jiang, Z., El-Brolosy, M.A., Serobyan, V., Welker, J.M., Retzer, N., Dooley, C.M., Jakutis, G., Juan, T., Fukuda, N., Maischein, H.M., Balciunas, D., Stainier, D.Y.R. (2022) Parental mutations influence wild-type offspring via transcriptional adaptation. Science advances. 8:eabj2029
- Metikala, S., Warkala, M., Casie Chetty, S., Chestnut, B., Rufin Florat, D., Plender, E., Nester, O., Koenig, A.L., Astrof, S., Sumanas, S. (2022) Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Developmental Cell. 57(6):767-782.e6
- Wu, M., Chen, Q., Li, J., Xu, Y., Lian, J., Liu, Y., Meng, P., Zhang, Y. (2022) Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish. Frontiers in cell and developmental biology. 9:786426
- Jin, S., Na, H., Jeon, H., Park, J., Choe, C.P. (2021) egfl6 expression in the pharyngeal pouch is dispensable for craniofacial development. Animal cells and systems. 25:255-263
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- El-Brolosy, M.A., Kontarakis, Z., Rossi, A., Kuenne, C., Günther, S., Fukuda, N., Kikhi, K., Boezio, G.L.M., Takacs, C.M., Lai, S.L., Fukuda, R., Gerri, C., Giraldez, A.J., Stainier, D.Y.R. (2019) Genetic compensation triggered by mutant mRNA degradation. Nature. 568(7751):193-197
- Hoshijima, K., Jurynec, M.J., Klatt Shaw, D., Jacobi, A.M., Behlke, M.A., Grunwald, D.J. (2019) Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. Developmental Cell. 51(5):645-657.e4
1 - 10 of 30
Show