Gene

sdha

ID
ZDB-GENE-040426-874
Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Symbol
sdha Nomenclature History
Previous Names
  • im:7141001
  • zgc:56051
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to act upstream of or within electron transport chain. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including adaxial cell; alar plate midbrain region; eye; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
mn121Allele with one deletionUnknownFrameshiftTALEN
sa23438Allele with one point mutationUnknownSplice SiteENU
sa36776Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-sdha
    Zhang et al., 2024
    TALEN1-sdha (2)
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    Human Disease
    Associated With sdha Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1GG Alliance Cardiomyopathy, dilated, 1GG 613642
    mitochondrial complex II deficiency Alliance Mitochondrial complex II deficiency, nuclear type 1 252011
    paraganglioma Alliance Pheochromocytoma/paraganglioma syndrome 5 614165
    Neurodegeneration with ataxia and late-onset optic atrophy 619259
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    Associated With sdha Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Binding_site IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
    Domain IPR003953 FAD-dependent oxidoreductase 2, FAD-binding domain
    Domain IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
    Family IPR011281 Succinate dehydrogenase, flavoprotein subunit
    Family IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
    1 - 5 of 9 Show all
    Domain Details Per Protein
    Protein Additional Resources Length FAD-dependent oxidoreductase 2, FAD-binding domain FAD-dependent oxidoreductase SdhA/FrdA/AprA FAD/NAD(P)-binding domain superfamily Fumarate reductase/succinate dehydrogenase, FAD-binding site Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily Succinate dehydrogenase, flavoprotein subunit Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
    UniProtKB:Q7ZVF3 InterPro 661
    UniProtKB:B2GQ13 InterPro 661
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    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 19
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA sdha-201 (1) Ensembl 2,543 nt
    ncRNA sdha-003 (1) Ensembl 806 nt
    ncRNA sdha-004 (1) Ensembl 700 nt
    ncRNA sdha-005 (1) Ensembl 752 nt
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    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    No data available
    Marker Relationships
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanSDHA5
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (4)
    MouseSdha13
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (1)
    Citations
    1 - 10 of 61
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