Gene
sdha
- ID
- ZDB-GENE-040426-874
- Name
- succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
- Symbol
- sdha Nomenclature History
- Previous Names
-
- im:7141001
- zgc:56051
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to act upstream of or within electron transport chain. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including adaxial cell; alar plate midbrain region; eye; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141001 (1 image)
- IMAGE:6897154 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sdha | Zhang et al., 2024 | |
| TALEN1-sdha | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1GG | Alliance | Cardiomyopathy, dilated, 1GG | 613642 |
| mitochondrial complex II deficiency | Alliance | Mitochondrial complex II deficiency, nuclear type 1 | 252011 |
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 5 | 614165 |
| Neurodegeneration with ataxia and late-onset optic atrophy | 619259 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR003952 | Fumarate reductase/succinate dehydrogenase, FAD-binding site |
| Domain | IPR003953 | FAD-dependent oxidoreductase 2, FAD-binding domain |
| Domain | IPR015939 | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal |
| Family | IPR011281 | Succinate dehydrogenase, flavoprotein subunit |
| Family | IPR014006 | Succinate dehydrogenase/fumarate reductase, flavoprotein subunit |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-dependent oxidoreductase 2, FAD-binding domain | FAD-dependent oxidoreductase SdhA/FrdA/AprA | FAD/NAD(P)-binding domain superfamily | Fumarate reductase/succinate dehydrogenase, FAD-binding site | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily | Succinate dehydrogenase, flavoprotein subunit | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily | Succinate dehydrogenase/fumarate reductase, flavoprotein subunit |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVF3 | InterPro | 661 | |||||||||
| UniProtKB:B2GQ13 | InterPro | 661 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-216M24 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-84F11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6897154 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7141001 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56051 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191735 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200910 (1) | 2576 nt | ||
| Genomic | GenBank:BX890617 (1) | 182182 nt | ||
| Polypeptide | UniProtKB:B2GQ13 (1) | 661 aa |
- She, P., Gao, B., Li, D., Wu, C., Zhu, X., He, Y., Mo, F., Qi, Y., Jin, D., Chen, Y., Zhao, X., Lin, J., Hu, H., Li, J., Zhang, B., Xie, P., Lin, C., Christoffels, V.M., Wu, Y., Zhu, P., Zhong, T.P. (2025) The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nature communications. 16:232232
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Zhang, Y., Liu, Y., Qin, W., Zheng, S., Xiao, J., Xia, X., Yuan, X., Zeng, J., Shi, Y., Zhang, Y., Ma, H., Varshney, G.K., Fei, J.F., Liu, Y. (2024) Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish. Nature communications. 15:95269526
- Légaré, V.P., Rampal, C.J., Gurberg, T.J.N., Aaltonen, M.J., Janer, A., Zinman, L., Shoubridge, E.A., Armstrong, G.A.B. (2023) Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response. Developmental Neurobiology. 83(1-2):54-69
- Wen, W., Guo, C., Chen, Z., Yang, D., Zhu, D., Jing, Q., Zheng, L., Sun, C., Tang, C. (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. PLoS One. 18:e0294700e0294700
- Zou, Y.Y., Tang, X.B., Chen, Z.L., Liu, B., Zheng, L., Song, M.Y., Xiao, Q., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2023) Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish. Frontiers in endocrinology. 14:11624851162485
- Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J. (2022) Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental Toxicology and Pharmacology. 93:103873
- Morgan, R., Andreassen, A.H., Åsheim, E.R., Finnøen, M.H., Dresler, G., Brembu, T., Loh, A., Miest, J.J., Jutfelt, F. (2022) Reduced physiological plasticity in a fish adapted to stable temperatures. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201919119
- Sabharwal, A., Campbell, J.M., Schwab, T.L., WareJoncas, Z., Wishman, M.D., Ata, H., Liu, W., Ichino, N., Hunter, D.E., Bergren, J.D., Urban, M.D., Urban, R.M., Holmberg, S.R., Kar, B., Cook, A., Ding, Y., Xu, X., Clark, K.J., Ekker, S.C. (2022) A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Genes. 13(8):
- Spelat, R., Ferro, F., Contessotto, P., Aljaabary, A., Martin-Saldaña, S., Jin, C., Karlsson, N.G., Grealy, M., Hilscher, M.M., Magni, F., Chinello, C., Kilcoyne, M., Pandit, A. (2022) Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration. Communications biology. 5:13651365
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