Gene

serpine2

ID
ZDB-GENE-040426-848
Name
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Symbol
serpine2 Nomenclature History
Previous Names
  • zgc:55929
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of plasminogen activation. Predicted to be active in extracellular space. Is expressed in midbrain hindbrain boundary; neural plate; olfactory system; otic vesicle; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la019423TgTransgenic insertionUnknownUnknownDNA
sa993Allele with one point mutationUnknownPremature StopENU
sa6397Allele with one point mutationUnknownSplice SiteENU
sa42621Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-serpine2
    Lin et al., 2025
    CRISPR2-serpine2
      Lin et al., 2025
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      Human Disease
      Associated With serpine2 Human Ortholog
      No data available
      Associated With serpine2 Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Conserved_site IPR023795 Serpin, conserved site
      Domain IPR023796 Serpin domain
      Family IPR000215 Serpin family
      Homologous_superfamily IPR036186 Serpin superfamily
      Homologous_superfamily IPR042178 Serpin superfamily, domain 1
      1 - 5 of 6 Show all
      Domain Details Per Protein
      Protein Additional Resources Length Serpin, conserved site Serpin domain Serpin family Serpin superfamily Serpin superfamily, domain 1 Serpin superfamily, domain 2
      UniProtKB:Q7ZVL5 InterPro 395
      1 - 1 of 1
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 15
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA serpine2-201 (1) Ensembl 1,609 nt
      mRNA serpine2-202 (1) Ensembl 1,191 nt
      1 - 2 of 2
      Interactions and Pathways
      No data available
      Antibodies
      No data available
      Plasmids
      No data available
      Constructs
      No data available
      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inFosmidCH1073-123J12ZFIN Curated Data
      Contained inFosmidCH1073-398D16ZFIN Curated Data
      EncodescDNAMGC:55929ZFIN Curated Data
      EncodescDNAMGC:191136ZFIN Curated Data
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanSERPINE22
      Conserved genome location (synteny) (1)
      Amino acid sequence comparison (1)
      MouseSerpine21
      Conserved genome location (synteny) (1)
      Amino acid sequence comparison (1)
      Citations
      1 - 10 of 12
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