Gene
hdac3
- ID
- ZDB-GENE-040426-847
- Name
- histone deacetylase 3
- Symbol
- hdac3 Nomenclature History
- Previous Names
-
- zgc:55927 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein lysine delactylase activity; and transcription corepressor activity. Acts upstream of or within several processes, including angiogenesis; liver development; and posterior lateral line development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Is expressed in several structures, including axial blood vessel; blood vessel; digestive system; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55927 (1 image)
- MGC:55927 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone deacetylase domain | Histone deacetylase domain superfamily | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q803C3 | InterPro | 428 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194M19 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-87D10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55927 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200990 (1) | 2069 nt | ||
| Genomic | GenBank:CR354536 (1) | 157228 nt | ||
| Polypeptide | UniProtKB:Q803C3 (1) | 428 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | HDAC3 | 5 | Amino acid sequence comparison (2) |
- Portolés, I., Ribera, J., Fernandez-Galán, E., Lecue, E., Casals, G., Melgar-Lesmes, P., Fernández-Varo, G., Boix, L., Sanduzzi, M., Aishwarya, V., Reig, M., Jiménez, W., Morales-Ruiz, M. (2024) Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. International Journal of Molecular Sciences. 25(7):
- Zhou, R., Ding, R.C., Yu, Q., Qiu, C.Z., Zhang, H.Y., Yin, Z.J., Ren, D.L. (2024) Metformin Attenuates Neutrophil Recruitment through the H3K18 Lactylation/Reactive Oxygen Species Pathway in Zebrafish. Antioxidants (Basel, Switzerland). 13(2):
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Volpatti, J.R., Ghahramani-Seno, M.M., Mansat, M., Sabha, N., Sarikaya, E., Goodman, S.J., Chater-Diehl, E., Celik, A., Pannia, E., Froment, C., Combes-Soia, L., Maani, N., Yuki, K.E., Chicanne, G., Uusküla-Reimand, L., Monis, S., Alvi, S.A., Genetti, C.A., Payrastre, B., Beggs, A.H., Bonnemann, C.G., Muntoni, F., Wilson, M.D., Weksberg, R., Viaud, J., Dowling, J.J. (2022) X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. Acta Neuropathologica. 144(3):537-563
- Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054
- Mao, Y., Zong, Z., Dang, Y., Yu, L., Liu, C., Wang, J. (2021) Promotion effect of microcystin-LR on liver tumor progression in krasV12 transgenic zebrafish following acute or subacute exposure. Ecotoxicology and environmental safety. 224:112673
- Kiyooka, M., Shimizu, Y., Ohshima, T. (2020) Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum. Biochemical and Biophysical Research Communications. 529:366-371
- Blanc, M., Rüegg, J., Scherbak, N., Keiter, S.H. (2019) Environmental chemicals differentially affect epigenetic-related mechanisms in the zebrafish liver (ZF-L) cell line and in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 215:105272
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Laing, L.V., Viana, J., Dempster, E., Uren Webster, T.M., van Aerle, R., Mill, J., Santos, E.M. (2018) Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 222:16-25
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