Gene
cdc5l
- ID
- ZDB-GENE-040426-821
- Name
- CDC5 cell division cycle 5-like (S. pombe)
- Symbol
- cdc5l Nomenclature History
- Previous Names
-
- zgc:55853
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing; cell division; and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of Prp19 complex and spliceosomal complex. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55853 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16815 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22983 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22984 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39137 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42854 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001005 | SANT/Myb domain |
| Domain | IPR017930 | Myb domain |
| Domain | IPR021786 | Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal |
| Domain | IPR047240 | Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain |
| Family | IPR047242 | Pre-mRNA splicing factor component CDC5L/Cef1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Myb domain | Pre-mRNA splicing factor component CDC5L/Cef1 | Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain | Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal | SANT/Myb domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q803E9 | InterPro | 567 | ||||||
| UniProtKB:E9QIC1 | InterPro | 800 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-370H15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-202E13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55853 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192369 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201084 (1) | 2799 nt | ||
| Genomic | GenBank:BX927095 (2) | 211277 nt | ||
| Polypeptide | UniProtKB:E9QIC1 (1) | 800 aa |
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Xue, Y., Lv, J., Zhang, C., Wang, L., Ma, D., Liu, F. (2017) The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b. Developmental Cell. 42(4):349-362.e4
- Zhang, Y., Xue, Y., Cao, C., Huang, J., Hong, Q., Hai, T., Jia, Q., Wang, X., Qin, G., Yao, J., Wang, X., Zheng, Q., Zhang, R., Li, Y., Luo, A., Zhang, N., Shi, G., Wang, Y., Ying, H., Liu, Z., Wang, H., Meng, A., Zhou, Q., Wei, H., Liu, F., Zhao, J. (2017) Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 130(20):2161-2170
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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