Gene
cdc14b
- ID
- ZDB-GENE-040426-820
- Name
- cell division cycle 14B
- Symbol
- cdc14b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Acts upstream of or within cilium assembly. Located in condensed chromosome; nucleolus; and spindle. Is expressed in EVL and proliferative region. Orthologous to several human genes including CDC14B (cell division cycle 14B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55844 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026336Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa21171 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| vu426Tg | Transgenic insertion | Intron 1 | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cdc14b | N/A | (2) |
| MO2-cdc14b | N/A | Clément et al., 2011 |
| MO3-cdc14b | N/A | Clément et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dual specificity phosphatase, catalytic domain | Dual-specificity phosphatase CDC14, C-terminal | Dual specificity protein phosphatase domain | Dual specificity/tyrosine protein phosphatase, N-terminal | Protein Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F8W2B2 | InterPro | 476 | |||||||||
| UniProtKB:A0A8M2BE48 | InterPro | 519 | |||||||||
| UniProtKB:A0A8M9QII0 | InterPro | 419 | |||||||||
| UniProtKB:A0A8M9Q9K5 | InterPro | 451 | |||||||||
| UniProtKB:A0A8M2BE70 | InterPro | 508 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
cdc14b-203
(1)
|
Ensembl | 851 nt | ||
| antisense |
ottdart00000059745
(1)
|
Ensembl | 1,356 nt | ||
| mRNA |
cdc14b-202
(1)
|
Ensembl | 863 nt | ||
| mRNA |
cdc14b-204
(1)
|
Ensembl | 868 nt | ||
| mRNA |
cdc14b-205
(1)
|
Ensembl | 1,484 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-129K1 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-145E6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55844 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192648 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200179 (1) | 1991 nt | ||
| Genomic | GenBank:CU896541 (1) | 104170 nt | ||
| Polypeptide | UniProtKB:A0A8M2BE48 (1) | 519 aa |
- Sun, K., Han, Y., Li, J., Yu, S., Huang, Y., Zhang, Y., Reilly, J., Tu, J., Gao, P., Jia, D., Chen, X., Hu, H., Ren, M., Li, P., Luo, J., Ren, X., Zhang, X., Shu, X., Liu, F., Liu, M., Tang, Z. (2023) The splicing factor DHX38 enables retinal development through safeguarding genome integrity. iScience. 26:108103108103
- Tu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M.T.S., Lu, Q., Liu, M. (2022) Dhx38 regulates the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Development (Cambridge, England). 149(17)
- Beaudoin, J.D., Novoa, E.M., Vejnar, C.E., Yartseva, V., Takacs, C.M., Kellis, M., Giraldez, A.J. (2018) Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Nature structural & molecular biology. 25(8):677-686
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Clément, A., Solnica-Krezel, L., and Gould, K.L. (2012) Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(12):1911-1921
- Clément, A., Solnica-Krezel, L., and Gould, K.L. (2011) The Cdc14B phosphatase contributes to ciliogenesis in zebrafish. Development (Cambridge, England). 138(2):291-302
- Pei, W., Noushmehr, H., Costa, J., Ouspenskaia, M.V., Elkahloun, A.G., and Feldman, B. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Developmental Biology. 310(1):10-22
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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