Gene
xab2
- ID
- ZDB-GENE-040426-685
- Name
- XPA binding protein 2
- Symbol
- xab2 Nomenclature History
- Previous Names
-
- zgc:63498
- zgc:63949 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be involved in generation of catalytic spliceosome for first transesterification step. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type catalytic step 2 spliceosome; and post-mRNA release spliceosomal complex. Orthologous to human XAB2 (XPA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14562 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33316 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33317 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40167 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44578 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR055430 | Pre-mRNA-splicing factor Syf1/CRNKL1-like, C-terminal HAT-repeats domain |
| Domain | IPR055433 | Pre-mRNA-splicing factor Syf1-like, N-terminal HAT-repeats domain |
| Domain | IPR056350 | Pre-mRNA-splicing factor SYF1, central HAT repeats domain |
| Family | IPR045075 | Pre-mRNA-splicing factor Syf1-like |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | HAT (Half-A-TPR) repeat | Pre-mRNA-splicing factor SYF1, central HAT repeats domain | Pre-mRNA-splicing factor Syf1/CRNKL1-like, C-terminal HAT-repeats domain | Pre-mRNA-splicing factor Syf1-like | Pre-mRNA-splicing factor Syf1-like, N-terminal HAT-repeats domain | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LY92 | InterPro | 851 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-209E8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63498 | ||
| Encodes | cDNA | MGC:63949 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198247 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044783 (1) | 2903 nt | ||
| Genomic | GenBank:BX005479 (2) | 171793 nt | ||
| Polypeptide | UniProtKB:Q1LY92 (1) | 851 aa |
- Honjo, Y., Ichinohe, T. (2019) Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Cell biology international. 43(5):516-527
- Shi, W., Shao, T., Li, J.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 203(9):2425-2442
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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