Gene
krt15
- ID
- ZDB-GENE-040426-2931
- Name
- keratin 15
- Symbol
- krt15 Nomenclature History
- Previous Names
-
- wu:fa91c06
- wu:fa95d04
- zgc:55334
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of skin epidermis. Predicted to be involved in morphogenesis of an epithelium. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Is expressed in digestive system; lateral line system; and trunk. Orthologous to several human genes including KRT15 (keratin 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55334 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011923Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017658Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027220Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027221Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6196 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35039 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35040 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-krt15 | (2) | |
| CRISPR2-krt15 | (4) | |
| CRISPR3-krt15 | (2) | |
| CRISPR4-krt15 | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament, rod domain | Keratin, type I |
|---|---|---|---|---|
| UniProtKB:B0UYS0 | InterPro | 460 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(krt15:LY-RFP) |
|
| 1 | Wong et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28E7 | ZFIN Curated Data | |
| Encodes | EST | fa91c06 | ||
| Encodes | EST | fa95d04 | ||
| Encodes | cDNA | MGC:55334 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191718 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:92147 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213523 (1) | 1581 nt | ||
| Genomic | GenBank:CR556712 (2) | 112718 nt | ||
| Polypeptide | UniProtKB:B0UYS0 (1) | 460 aa |
- Ho, M., Thompson, B., Fisk, J.N., Nebert, D.W., Bruford, E.A., Vasiliou, V., Bunick, C.G. (2022) Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human genomics. 16:1
- Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
- England, S.J., Cerda, G.A., Kowalchuk, A., Sorice, T., Grieb, G., Lewis, K.E. (2020) Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 216(4):1153-1185
- Han, C.R., Holmsen, E., Carrington, B., Bishop, K., Zhu, Y.J., Starost, M., Meltzer, P., Sood, R., Liu, P., Cheng, S.Y. (2020) Generation of novel genetic models to dissect resistance to thyroid hormone receptor alpha in zebrafish. Thyroid : official journal of the American Thyroid Association. 30(2):314-328
- Wong, M., Newton, L.R., Hartmann, J., Hennrich, M.L., Wachsmuth, M., Ronchi, P., Guzmán-Herrera, A., Schwab, Y., Gavin, A.C., Gilmour, D. (2020) Dynamic Buffering of Extracellular Chemokine by a Dedicated Scavenger Pathway Enables Robust Adaptation during Directed Tissue Migration. Developmental Cell. 52(4):492-508.e10
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Cokus, S.J., De La Torre, M., Medina, E.F., Rasmussen, J.P., Ramirez-Gutierrez, J., Sagasti, A., Wang, F. (2019) Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos. G3 (Bethesda). 9(10):3439-3452
- Yang, L., Zeng, C., Zhang, Y., Wang, F., Takamiya, M., Strähle, U. (2019) Functions of thioredoxin1 in brain development and in response to environmental chemicals in zebrafish embryos. Toxicology letters. 314:43-52
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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