Gene
crip2
- ID
- ZDB-GENE-040426-2889
- Name
- cysteine-rich protein 2
- Symbol
- crip2 Nomenclature History
- Previous Names
-
- wu:fb30h10
- zgc:55408
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within heart contraction and heart development. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; neural crest; and notochord. Orthologous to human CRIP2 (cysteine rich protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55408 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ouc303 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-crip2 | Yang et al., 2025 | |
MO1-crip2 | N/A | Sun et al., 2008 |
MO2-crip2 | N/A | Sun et al., 2008 |
MO3-crip2 | N/A | Kim et al., 2014 |
MO4-crip2 | N/A | Straubinger et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001781 | Zinc finger, LIM-type |
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Domain Details Per Protein
Protein | Additional Resources | Length | Zinc finger, LIM-type |
---|---|---|---|
UniProtKB:F1QZB0 | InterPro | 206 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(crip2:crip2-EGFP) |
|
|
| 1 | Yang et al., 2025 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-166M10 | ZFIN Curated Data | |
Encodes | EST | fb30h10 | ZFIN Curated Data | |
Encodes | cDNA | MGC:55408 | ZFIN Curated Data | |
Encodes | cDNA | MGC:175083 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191473 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213497 (1) | 2016 nt | ||
Genomic | GenBank:AL929543 (2) | 147094 nt | ||
Polypeptide | UniProtKB:F1QZB0 (1) | 206 aa |
- Yang, S., Zhang, X., Li, X., Li, H. (2025) Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation. Cellular and molecular life sciences : CMLS. 82:110110
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Holowiecki, A., Linstrum, K., Ravisankar, P., Chetal, K., Salomonis, N., Waxman, J.S. (2020) Pbx4 limits heart size and fosters arch artery formation through partitioning second heart field progenitors and restricting proliferation. Development (Cambridge, England). 147(5):
- Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
- Wang, J., Luo, J., Chen, Q., Wang, X., He, J., Zhang, W., Yin, Z., Zheng, F., Pan, H., Li, T., Lou, Q., Wang, B. (2018) Identification of LBX2 as a novel causal gene of atrial septal defect. International Journal of Cardiology. 265:188-194
- Mortensen, S.A., Skov, L.L., Kjaer-Sorensen, K., Hansen, A.G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J.C., Oxvig, C., Thiel, S., Degn, S.E. (2017) Endogenous Natural Complement Inhibitor Regulates Cardiac Development. Journal of immunology (Baltimore, Md. : 1950). 198(8):3118-3126
- Straubinger, J., Boldt, K., Kuret, A., Deng, L., Krattenmacher, D., Bork, N., Desch, M., Feil, R., Feil, S., Nemer, M., Ueffing, M., Ruth, P., Just, S., Lukowski, R. (2017) Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(4):1620-1638
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Etard, C., Armant, O., Roostalu, U., Gourain, V., Ferg, M., Strähle, U. (2015) Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Genome biology. 16:267
- Kim, J.D., Kim, H.J., Koun, S., Ham, H.J., Kim, M.J., Rhee, M., Huh, T.L. (2014) Zebrafish Crip2 Plays a Critical Role in Atrioventricular Valve Development by Downregulating the Expression of ECM Genes in the Endocardial Cushion. Molecules and cells. 37(5):406-11
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