Gene

sec23a

ID

ZDB-GENE-040426-2823

Name

Sec23 homolog A, coat complex II component

Symbol

sec23a Nomenclature History

Previous Names

cru
crusher
wu:fc10f08
wu:fi15g03
zgc:55534

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity and zinc ion binding activity. Acts upstream of or within pectoral fin morphogenesis; protein targeting; and skeletal system development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including cartilage element; hatching gland; notochord; polster; and tail bud. Used to study craniolenticulosutural dysplasia. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159902 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sec23a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
craniolenticulosutural dysplasia	Alliance	Craniolenticulosutural dysplasia	607812

Associated With sec23a Via Experimental Models

Human Disease	Fish	Conditions	Citations
craniolenticulosutural dysplasia	sec23a^m299/m299 (AB)	standard conditions	Cox et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006895	Zinc finger, Sec23/Sec24-type
Domain	IPR006896	Sec23/Sec24, trunk domain
Domain	IPR006900	Sec23/Sec24, helical domain
Domain	IPR007123	Gelsolin-like domain
Domain	IPR012990	Sec23/Sec24 beta-sandwich
Domain	IPR037550	Sec23, C-terminal
Family	IPR037364	Protein transport protein Sec23
Homologous_superfamily	IPR029006	ADF-H/Gelsolin-like domain superfamily
Homologous_superfamily	IPR036174	Zinc finger, Sec23/Sec24-type superfamily
Homologous_superfamily	IPR036175	Sec23/Sec24 helical domain superfamily
Homologous_superfamily	IPR036180	Gelsolin-like domain superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	ADF-H/Gelsolin-like domain superfamily	Gelsolin-like domain	Gelsolin-like domain superfamily	Protein transport protein Sec23	Sec23, C-terminal	Sec23/Sec24 beta-sandwich	Sec23/Sec24, helical domain	Sec23/Sec24 helical domain superfamily	Sec23/Sec24, trunk domain	von Willebrand factor A-like domain superfamily	Zinc finger, Sec23/Sec24-type	Zinc finger, Sec23/Sec24-type superfamily
UniProtKB:B2GSV7	InterPro	765
UniProtKB:Q7SZE5	InterPro	765

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sec23a-201 (1) Ensembl	Ensembl	5,564 nt	Select Tool ZFIN BLAST
mRNA	sec23a-202 (1) Ensembl	Ensembl	2,304 nt	Select Tool ZFIN BLAST
mRNA	sec23a-203 (1) Ensembl	Ensembl	3,150 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations