Gene

sec23a

ID
ZDB-GENE-040426-2823
Name
Sec23 homolog A, coat complex II component
Symbol
sec23a Nomenclature History
Previous Names
  • cru
  • crusher
  • wu:fc10f08
  • wu:fi15g03
  • zgc:55534
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity and zinc ion binding activity. Acts upstream of or within pectoral fin morphogenesis; protein targeting; and skeletal system development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including cartilage element; hatching gland; notochord; polster; and tail bud. Used to study craniolenticulosutural dysplasia. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la019891TgTransgenic insertionUnknownUnknownDNA
la019892TgTransgenic insertionUnknownUnknownDNA
m299Allele with one point mutationUnknownUnknownENU
sa6460Allele with one point mutationUnknownPremature StopENU
uq22bhAllele with one point mutationUnknownUnknownENU
uq23bhAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With sec23a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
craniolenticulosutural dysplasia Alliance Craniolenticulosutural dysplasia 607812
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Associated With sec23a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006895 Zinc finger, Sec23/Sec24-type
Domain IPR006896 Sec23/Sec24, trunk domain
Domain IPR006900 Sec23/Sec24, helical domain
Domain IPR007123 Gelsolin-like domain
Domain IPR012990 Sec23/Sec24 beta-sandwich
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Domain Details Per Protein
Protein Additional Resources Length ADF-H/Gelsolin-like domain superfamily Gelsolin-like domain Gelsolin-like domain superfamily Protein transport protein Sec23 Sec23, C-terminal Sec23/Sec24 beta-sandwich Sec23/Sec24, helical domain Sec23/Sec24 helical domain superfamily Sec23/Sec24, trunk domain von Willebrand factor A-like domain superfamily Zinc finger, Sec23/Sec24-type Zinc finger, Sec23/Sec24-type superfamily
UniProtKB:B2GSV7 InterPro 765
UniProtKB:Q7SZE5 InterPro 765
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sec23a-201 (1) Ensembl 5,564 nt
mRNA sec23a-202 (1) Ensembl 2,304 nt
mRNA sec23a-203 (1) Ensembl 3,150 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(-1.7col2a1a:sec23a-2A-EGFP)
  • Danio rerio
1Cox et al., 2017
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Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSEC23A14
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
MouseSec23a12
Amino acid sequence comparison (1)
Citations
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