Gene
ugt1ab
- ID
- ZDB-GENE-040426-2762
- Name
- UDP glucuronosyltransferase 1 family a, b
- Symbol
- ugt1ab Nomenclature History
- Previous Names
-
- ugt1a3
- zgc:123097
- zgc:66393
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables glucuronosyltransferase activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in intestinal bulb; intestine; liver; renal system; and testis.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112502 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8443 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8617 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15206 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18078 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27349 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34568 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | UDP-glucuronosyl/UDP-glucosyltransferase | UDP-glycosyltransferase | UDP-glycosyltransferase family, conserved site |
|---|---|---|---|---|---|
| UniProtKB:F1R1P2 | InterPro | 536 | |||
| UniProtKB:A0A2R8QML4 | InterPro |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ugt1a1-203
(1)
|
Ensembl | 1,106 nt | ||
| mRNA |
ugt1a1-209
(1)
|
Ensembl | 1,082 nt | ||
| mRNA |
ugt1a1-210
(1)
|
Ensembl | 1,103 nt | ||
| mRNA |
ugt1a1-211
(1)
|
Ensembl | 1,042 nt | ||
| mRNA |
ugt1a2-201
(1)
|
Ensembl | 1,964 nt |
1 - 5 of 11 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-226C11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66393 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213422 (1) | 1918 nt | ||
| Genomic | GenBank:AL954329 (1) | 194284 nt | ||
| Polypeptide | UniProtKB:F1R1P2 (2) | 536 aa |
No data available
- Yang, L., Tu, P.H., Zhang, C.X., Xie, R.R., Dong, M., Jing, Y., Chen, X., Wei, G., Song, H.D. (2023) Influence of two anti-tumor drugs, pazopanib, and axitinib, on the development and thyroid-axis of zebrafish (Danio rerio) embryos/larvae. Frontiers in endocrinology. 14:12046781204678
- Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870
- Wang, H., Dong, F., Zhao, Y., Fu, S., Zhao, H., Liu, S., Zhang, W., Hu, F. (2022) Exposure to diclofenac alters thyroid hormone levels and transcription of genes involved in the hypothalamic-pituitary-thyroid axis in zebrafish embryos/larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 257:109335
- Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176
- Hu, F., Zhao, Y., Yuan, Y., Yin, L., Dong, F., Zhang, W., Chen, X. (2021) Effects of environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) on early life stages of zebrafish (Danio rerio). Environmental Toxicology and Pharmacology. 83:103600
- Jin, M., Dang, J., Paudel, Y.N., Wang, X., Wang, B., Wang, L., Li, P., Sun, C., Liu, K. (2021) The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. The Science of the total environment. 776:145963
- Kim, J., Lee, G., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Thyroid disrupting effects of perfluoroundecanoic acid and perfluorotridecanoic acid in zebrafish (Danio rerio) and rat pituitary (GH3) cell line. Chemosphere. 262:128012
- Marqueño, A., Flores, C., Casado, M., Porte, C. (2021) Dysregulation of lipid metabolism in PLHC-1 and ZFL cells exposed to tributyltin an all-trans retinoic acid. Aquatic toxicology (Amsterdam, Netherlands). 231:105733
- Martín, M., Modenutti, C.P., Gil Rosas, M.L., Peyret, V., Geysels, R.C., Bernal Barquero, C.E., Sobrero, G., Muñoz, L., Signorino, M., Testa, G., Miras, M.B., Masini-Repiso, A.M., Calcaterra, N.B., Coux, G., Carrasco, N., Martí, M.A., Nicola, J.P. (2021) A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. The Journal of clinical endocrinology and metabolism. 106(7):1867-1881
- Wang, B., Liu, L., Li, Y., Zou, J., Li, D., Zhao, D., Li, W., Sun, W. (2021) Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae. Toxicology. 456:152786
1 - 10 of 92
Show