Gene
pdha1a
- ID
- ZDB-GENE-040426-2719
- Name
- pyruvate dehydrogenase E1 subunit alpha 1a
- Symbol
- pdha1a Nomenclature History
- Previous Names
-
- pdha1
- im:6895726
- wu:fd18b01
- wu:fo96f03
- zgc:73271
- zgc:86692
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in pyruvate decarboxylation to acetyl-CoA. Predicted to act upstream of or within glucose metabolic process. Predicted to be located in mitochondrial matrix. Is expressed in several structures, including adaxial cell; alar plate midbrain region; heart tube; musculature system; and pronephric duct. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6895726 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sandoval et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la029069Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa20403 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
pyruvate decarboxylase deficiency | Alliance | Pyruvate dehydrogenase E1-alpha deficiency | 312170 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001017 | Dehydrogenase, E1 component |
Family | IPR017597 | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y |
Family | IPR050642 | Pyruvate Dehydrogenase E1 Alpha Subunit |
Homologous_superfamily | IPR029061 | Thiamin diphosphate-binding fold |
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Domain Details Per Protein
Protein | Additional Resources | Length | Dehydrogenase, E1 component | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y | Pyruvate Dehydrogenase E1 Alpha Subunit | Thiamin diphosphate-binding fold |
---|---|---|---|---|---|---|
UniProtKB:Q6P948 | InterPro | 393 | ||||
UniProtKB:A0A0R4IT09 | InterPro | 400 | ||||
UniProtKB:A0AB32TT78 | InterPro | 411 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
pdha1a-201
(1)
|
Ensembl | 2,349 nt | ||
mRNA |
pdha1a-202
(1)
|
Ensembl | 1,479 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:LOXP-STOP-LOXP-pdha1a-2A-mCherry,cryaa:Cerulean) |
| 1 | Fukuda et al., 2020 | ||
Tg(myl7:pdha1a-2A-tdTomato) |
| 1 | Fukuda et al., 2019 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-114C12 | ZFIN Curated Data | |
Encodes | EST | fd18b01 | ZFIN Curated Data | |
Encodes | EST | fo96f03 | ZFIN Curated Data | |
Encodes | EST | IMAGE:6895726 | Thisse et al., 2004 | |
Encodes | EST | IMAGE:7149029 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:73271 | ZFIN Curated Data | |
Encodes | cDNA | MGC:86692 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213393 (1) | 2377 nt | ||
Genomic | GenBank:AL928875 (1) | 158038 nt | ||
Polypeptide | UniProtKB:A0AB32TT78 (1) | 411 aa |
- Lin, J., Li, X., Lu, K., Song, K., Wang, L., Dai, W., Mohamed, M., Zhang, C. (2024) Low phosphorus causes hepatic energy metabolism disorder through Dynamin-related protein 1-mediated mitochondrial fission in fish. The Journal of nutrition. 155(1):132-152
- Xu, S.S., Li, Y., Wang, H.P., Chen, W.B., Wang, Y.Q., Song, Z.W., Liu, H., Zhong, S., Sun, Y.H. (2023) Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Zoological research. 44:63-77
- Zhou, W.H., Luo, Y., Li, R.X., Degrace, P., Jourdan, T., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2023) Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of raptor in zebrafish. The Journal of biological chemistry. 299(10):105220
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
- Shankar, P., Garcia, G.R., LaDu, J.K., Sullivan, C.M., Dunham, C.L., Goodale, B.C., Waters, K.M., Stanisheuski, S., Maier, C.S., Thunga, P., Reif, D.M., Tanguay, R.L. (2022) The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 187(2):325-344
- Wang, J.G., Zhao, S.H., Qian, Y.C., Qian, Y.F., Liu, Y.C., Qiao, F., Luo, Y., Zhang, M.L., Du, Z.Y. (2022) The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism. The British journal of nutrition. 130(4):588-603
- Li, X.Y., Qin, Y.J., Wang, Y., Huang, T., Zhao, Y.H., Wang, X.H., Martyniuk, C.J., Yan, B. (2021) Relative comparison of strobilurin fungicides at environmental levels: Focus on mitochondrial function and larval activity in early staged zebrafish (Danio rerio). Toxicology. 452:152706
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
- Li, L.Y., Lv, H.B., Jiang, Z.Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2020) Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish. The Journal of physiology. 598(20):4537-4553
- Fukuda, R., Aharonov, A., Ong, Y.T., Stone, O.A., El-Brolosy, M., Maischein, H.M., Potente, M., Tzahor, E., Stainier, D.Y. (2019) Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. eLIFE. 8:
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