Gene
msmo1
- ID
- ZDB-GENE-040426-2670
- Name
- methylsterol monooxygenase 1
- Symbol
- msmo1 Nomenclature History
- Previous Names
-
- koliber (1)
- sc4mol
- wu:fb59g06
- wu:fb66e06
- zgc:56437
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable C-4 methylsterol oxidase activity. Acts upstream of or within cholesterol biosynthetic process and regulation of chondrocyte differentiation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including head; hypural; integument; pleuroperitoneal region; and yolk syncytial layer. Used to study chondrodysplasia punctata. Orthologous to human MSMO1 (methylsterol monooxygenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Anderson et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-msmo1 | (2) | |
| CRISPR2-msmo1 | Anderson et al., 2020 | |
| CRISPR3-msmo1 | (2) | |
| CRISPR4-msmo1 | (2) |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Microcephaly, congenital cataract, and psoriasiform dermatitis | 616834 |
1 - 1 of 1
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chondrodysplasia punctata | msmo1nu81/+; msmo1nu7/+ | standard conditions | Anderson et al., 2020 |
| chondrodysplasia punctata | msmo1nu7/nu7 | standard conditions | Anderson et al., 2020 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fatty acid hydroxylase | Sterol Desaturase and Related Enzymes |
|---|---|---|---|---|
| UniProtKB:Q7ZW77 | InterPro | 291 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp10a:msmo1,myl7:EGFP) |
|
| 1 | Anderson et al., 2020 | |
| Tg(hsp70l:msmo1-IRES-NLS-EGFP) |
| 1 | Anderson et al., 2020 |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-72G6 | ZFIN Curated Data | |
| Encodes | EST | fb59g06 | ZFIN Curated Data | |
| Encodes | EST | fb66e06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56437 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213353 (1) | 1587 nt | ||
| Genomic | GenBank:CR762472 (1) | 176472 nt | ||
| Polypeptide | UniProtKB:Q7ZW77 (1) | 291 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | MSMO1 | 4 | Amino acid sequence comparison (1) |
- Guirgis, F.W., Jacob, V., Wu, D., Henson, M., Daly-Crews, K., Hopson, C., Black, L.P., DeVos, E.L., Sulaiman, D., Labilloy, G., Brusko, T.M., Shavit, J.A., Bertrand, A., Feldhammer, M., Baskovich, B., Graim, K., Datta, S., Reddy, S.T. (2023) DHCR7 Expression Predicts Porsusor Outcomes and Mortality From Sepsis. Critical care explorations. 5:e0929e0929
- Jia, Q., Cao, Y., Zhang, M., Xing, Y., Xia, T., Guo, Y., Yue, Y., Li, X., Liu, X., Zhang, Y., Li, D., Li, Z., Tian, Y., Kang, X., Li, H. (2023) miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells. Poultry Science. 103:103200103200
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):
- Chen, B., Zheng, Y.M., Zhang, M.Q., Han, Y., Zhang, J.P., Hu, C.Q. (2020) Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model. Frontiers in pharmacology. 10:1504
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Porseryd, T., Volkova, K., Reyhanian Caspillo, N., Källman, T., Dinnetz, P., Porsh Hällström, I. (2017) Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior.. Frontiers in behavioral neuroscience. 11:69
- Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770
1 - 10 of 24
Show