Gene
timp2b
- ID
- ZDB-GENE-040426-2655
- Name
- TIMP metallopeptidase inhibitor 2b
- Symbol
- timp2b Nomenclature History
- Previous Names
-
- timp2l
- zgc:65967
- zgc:85799
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase inhibitor activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in caudal vein plexus; liver; ovarian follicle; and vasculature. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65967 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-timp2b | (2) | |
| CRISPR2-timp2b | (2) | |
| CRISPR3-timp2b | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Netrin domain | Protease inhibitor I35 (TIMP) | Proteinase inhibitor I35b (TIMP), C-terminal | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NUX9 | InterPro | 217 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
timp2b-201
(1)
|
Ensembl | 2,938 nt | ||
| mRNA |
timp2b-202
(1)
|
Ensembl | 1,989 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-78O6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-3M11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65967 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85799 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213296 (1) | 2956 nt | ||
| Genomic | GenBank:CT573423 (1) | 75691 nt | ||
| Polypeptide | UniProtKB:Q6NUX9 (1) | 217 aa |
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Jarayseh, T., Guillemyn, B., De Saffel, H., Bek, J.W., Syx, D., Symoens, S., Gansemans, Y., Van Nieuwerburgh, F., Jagadeesh, S., Raja, J., Malfait, F., Coucke, P.J., De Clercq, A., Willaert, A. (2023) A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract. Human genetics. 142(3):457-476
- Lv, H., Jin, Z., Wang, D., Guo, X., Wang, H., Yang, S. (2023) Erk5 functions in modulation of zebrafish intestinal permeability. Cell and tissue research. 393(2):281-296
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Solman, M., Blokzijl-Franke, S., Piques, F., Yan, C., Yang, Q., Strullu, M., Kamel, S.M., Ak, P., Bakkers, J., Langenau, D.M., Cave, H., den Hertog, J. (2022) Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects. eLIFE. 11:
- Brown, C., Mullins, L.J., Wesencraft, K., McConnell, G., Beltran, M., Henderson, N.C., Conway, B., Hoffmann, S., Rider, S., Mullins, J.J. (2021) scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 55:35-47
- J C Baker, S., Corrigan, E., Melnyk, N., Hilker, R., Van Der Kraak, G. (2021) Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation. General and comparative endocrinology. 311:113842
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Wang, W.Q., Qiu, S.W., Huang, S.S., Wang, G.J., Han, M.Y., Kang, D.Y., Yuan, Y.Y., Gao, X., Dai, P. (2021) Transcriptome analysis of the early stage ifnlr1-mutant zebrafish indicates the immune response to auditory dysfunction. Gene expression patterns : GEP. 43:119229
- Chen, R.Y., Lin, C.J., Liang, S.T., Villalobos, O., Villaflores, O.B., Lou, B., Lai, Y.H., Hsiao, C.D. (2020) UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Animals : an open access journal from MDPI. 10(6):
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