Gene
mre11a
- ID
- ZDB-GENE-040426-2638
- Name
- MRE11 homolog A, double strand break repair nuclease
- Symbol
- mre11a Nomenclature History
- Previous Names
-
- fc38f05
- wu:faa63d12
- wu:fc38f05
- zgc:64018
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within hematopoietic stem cell homeostasis and regulation of telomere maintenance. Predicted to be located in chromosome and nucleus. Predicted to be part of Mre11 complex. Predicted to be active in site of double-strand break. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64018 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia-telangiectasia-like disorder-1 | Alliance | Ataxia-telangiectasia-like disorder 1 | 604391 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007281 | Mre11, DNA-binding |
| Domain | IPR041796 | DNA double-strand break repair protein Mre11, N-terminal metallophosphatase domain |
| Family | IPR003701 | DNA double-strand break repair protein Mre11 |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
| Homologous_superfamily | IPR038487 | Mre11, capping domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA double-strand break repair protein Mre11 | DNA double-strand break repair protein Mre11, N-terminal metallophosphatase domain | Metallo-dependent phosphatase-like | Mre11, capping domain | Mre11, DNA-binding |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QPT3 | InterPro | 700 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mre11a-201
(1)
|
Ensembl | 2,157 nt | ||
| mRNA |
mre11a-202
(1)
|
Ensembl | 5,935 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Carrara, M., Gaillard, A.L., Brion, A., Duvernois-Berthet, E., Giovannangeli, C., Concordet, J.P., Pézeron, G. (2025) Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish. Scientific Reports. 15:48864886
- Lee, L., Perez Oliva, A.B., Martinez-Balsalobre, E., Churikov, D., Peter, J., Rahmouni, D., Audoly, G., Azzoni, V., Audebert, S., Camoin, L., Mulero, V., Cayuela, M.L., Kulathu, Y., Geli, V., Lachaud, C. (2021) UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Science advances. 7:eabc7371
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Zaksauskaite, R., Thomas, R.C., van Eeden, F., El-Khamisy, S.F. (2021) Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Science advances. 7(5):
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Bian, W.P., Chen, Y., Luo, J., Wang, C., Xie, S., Pei, D. (2019) A knock-in strategy for editing human and zebrafish mitochondrial DNA using mito-CRISPR/Cas9 system. ACS synthetic biology. 8(4):621-632
- Honjo, Y., Ichinohe, T. (2019) Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Cell biology international. 43(5):516-527
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Komoike, Y., Matsuoka, M. (2018) In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish. Journal of hazardous materials. 365:430-439
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
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