Gene
eif2b2
- ID
- ZDB-GENE-040426-2605
- Name
- eukaryotic translation initiation factor 2B, subunit 2 beta
- Symbol
- eif2b2 Nomenclature History
- Previous Names
-
- zgc:77512
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable translation initiation factor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 2. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Keefe et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Keefe et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17223 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 2 | Alliance | Leukoencephalopathy with vanishing white matter 2, with or without ovarian failure | 620312 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Eukaryotic initiation factor 2B subunit beta | Initiation factor 2B-like, C-terminal | Initiation factor 2B-related | NagB/RpiA transferase-like |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NXC7 | InterPro | 355 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2b2-201
(1)
|
Ensembl | 1,247 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-199I12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77512 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212903 (1) | 1211 nt | ||
| Genomic | GenBank:BX936455 (1) | 123707 nt | ||
| Polypeptide | UniProtKB:Q6NXC7 (1) | 355 aa |
- Wang, Q., Zhang, L., Zhu, C., Lu, K., Wu, J., Liang, X.F. (2025) Fosab, but not fosaa, plays important role in learning and memory in fish-insights from zebrafish gene knockout study. Frontiers in cell and developmental biology. 13:15030661503066
- Kubra, K., Gaddu, G.K., Liongue, C., Heidary, S., Ward, A.C., Dhillon, A.S., Basheer, F. (2022) Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. International Journal of Molecular Sciences. 23(17)
- Keefe, M.D., Soderholm, H.E., Shih, H.Y., Stevenson, T.J., Glaittli, K.A., Bowles, D.M., Scholl, E., Colby, S., Merchant, S., Hsu, E.W., Bonkowsky, J.L. (2020) Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. eLIFE. 9:
- Boczonadi, V., Müller, J.S., Pyle, A., Munkley, J., Dor, T., Quartararo, J., Ferrero, I., Karcagi, V., Giunta, M., Polvikoski, T., Birchall, D., Princzinger, A., Cinnamon, Y., Lützkendorf, S., Piko, H., Reza, M., Florez, L., Santibanez-Koref, M., Griffin, H., Schuelke, M., Elpeleg, O., Kalaydjieva, L., Lochmüller, H., Elliott, D.J., Chinnery, P.F., Edvardson, S., Horvath, R. (2014) EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nature communications. 5:4287
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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