Gene
itgb1b.2
- ID
- ZDB-GENE-040426-2598
- Name
- integrin, beta 1b.2
- Symbol
- itgb1b.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity; fibronectin binding activity; and protein kinase binding activity. Predicted to contribute to C-X3-C chemokine binding activity and laminin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface; focal adhesion; and synapse. Is expressed in several structures, including gill; integument; liver; periderm; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85632 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la010116Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa18076 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33006 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR002369 | Integrin beta subunit, VWA domain |
Domain | IPR033760 | Integrin beta N-terminal |
Domain | IPR040622 | Integrin beta, epidermal growth factor-like domain 1 |
Family | IPR015812 | Integrin beta subunit |
Homologous_superfamily | IPR032695 | Integrin domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Integrin beta, epidermal growth factor-like domain 1 | Integrin beta N-terminal | Integrin beta subunit | Integrin beta subunit, VWA domain | Integrin domain superfamily | von Willebrand factor A-like domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QHH8 | InterPro | 550 | ||||||
UniProtKB:Q19U09 | InterPro | 613 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
itgb1b.2-201
(1)
|
Ensembl | 2,383 nt | ||
mRNA |
itgb1b.2-202
(1)
|
Ensembl | 2,133 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-6M13 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85632 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212928 (1) | 2383 nt | ||
Genomic | GenBank:CU693495 (2) | 161233 nt | ||
Polypeptide | UniProtKB:Q19U09 (1) | 613 aa |
No data available
- Bao, J., Yu, X., Ping, X., Shentu, X., Zou, J. (2023) Znf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome. Investigative ophthalmology & visual science. 64:2929
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Zhou, C., Zhao, W., Zhang, S., Ma, J., Sultan, Y., Li, X. (2022) High-throughput transcriptome sequencing reveals the key stages of cardiovascular development in zebrafish embryos. BMC Genomics. 23:587
- Song, J., Eghan, K., Lee, S., Park, J.S., Yoon, S., Pimtong, W., Kim, W.K. (2020) A Phenotypic and Genotypic Evaluation of Developmental Toxicity of Polyhexamethylene Guanidine Phosphate Using Zebrafish Embryo/Larvae. Toxics. 8(2):
- Iida, A., Wang, Z., Hirata, H., Sehara-Fujisawa, A. (2018) Integrin β1 activity is required for cardiovascular formation in zebrafish. Genes to cells : devoted to molecular & cellular mechanisms. 23(11):938-951
- Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R. (2017) Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos. Environmental science and pollution research international. 25(5):4023-4036
- Wang, X., Yuan, W., Wang, X., Qi, J., Qin, Y., Shi, Y., Zhang, J., Gong, J., Dong, Z., Liu, X., Sun, C., Chai, R., Le Noble, F., Liu, D. (2016) The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget. 7(47):77749-77763
- Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
- Hausen, J., Otte, J.C., Strähle, U., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R. (2015) Fold-change threshold screening: a robust algorithm to unmask hidden gene expression patterns in noisy aggregated transcriptome data. Environmental science and pollution research international. 22(21):16384-92
- Wang, X., Li, L., Liu, D. (2014) Expression analysis of integrin β1 isoforms during zebrafish embryonic development. Gene expression patterns : GEP. 16(2):86-92
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