Gene
socs3b
- ID
- ZDB-GENE-040426-2528
- Name
- suppressor of cytokine signaling 3b
- Symbol
- socs3b Nomenclature History
- Previous Names
-
- zgc:77038
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor binding activity. Acts upstream of or within brain development. Is expressed in eye; heart; lateral line ganglion; and segmental plate. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77038 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb32 | Allele with one delins | Unknown | Unknown | TALEN | |
| ihb36 | Allele with one deletion | Unknown | Unknown | TALEN | |
| mdu24 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa35352 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35353 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-socs3b | (2) | |
| CRISPR3-socs3b | (2) | |
| CRISPR4-socs3b | (3) | |
| CRISPR5-socs3b | Banks et al., 2021 | |
| CRISPR6-socs3b | Sobah et al., 2023 | |
| MO1-socs3b | N/A | (3) |
| MO2-socs3b | N/A | Yu et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SH2 domain | SH2 domain superfamily | SOCS3, SH2 domain | SOCS box domain | SOCS box-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYJ2 | InterPro | 210 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
socs3b-201
(1)
|
Ensembl | 2,155 nt | ||
| mRNA |
socs3b-202
(1)
|
Ensembl | 874 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-360C16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77038 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213304 (1) | 2079 nt | ||
| Genomic | GenBank:CU855552 (2) | 59655 nt | ||
| Polypeptide | UniProtKB:Q6NYJ2 (1) | 210 aa |
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Shin, K., Rodriguez-Parks, A., Kim, C., Silaban, I.M., Xia, Y., Sun, J., Dong, C., Keles, S., Wang, J., Cao, J., Kang, J. (2024) Harnessing the regenerative potential of interleukin11 to enhance heart repair. Nature communications. 15:96669666
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Soos, B.L., Ballinger, A., Weinstein, M., Foreman, H., Grampone, J., Weafer, S., Aylesworth, C., King, B.L. (2024) Color-Flu Fluorescent Reporter Influenza A Viruses Allow for In Vivo Studies of Innate Immune Function in Zebrafish. Viruses. 16(1):
- Xu, H., Cao, L., Chen, Y., Zhou, C., Xu, J., Zhang, Z., Li, X., Liu, L., Lu, J. (2024) Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration. Neural regeneration research. :
- Guo, Q.Q., Yuan, Y.Y., Sun, T.W., Wu, S.J., Li, X.H., Zhao, H.S. (2023) Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway. European review for medical and pharmacological sciences. 27:425442684254-4268
- Palsamy, K., Chen, J.Y., Skaggs, K., Qadeer, Y., Connors, M., Cutler, N., Richmond, J., Kommidi, V., Poles, A., Affrunti, D., Powell, C., Goldman, D., Parent, J.M. (2023) Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 71(11):2642-2663
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
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