Gene
slc5a2
- ID
- ZDB-GENE-040426-2498
- Name
- solute carrier family 5 member 2
- Symbol
- slc5a2 Nomenclature History
- Previous Names
-
- zgc:85792
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable D-glucose:sodium symporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in hatching gland; polster; and pronephric proximal convoluted tubule. Human ortholog(s) of this gene implicated in familial renal glucosuria and renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85792 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-slc5a2 | N/A | Shi et al., 2017 |
MO2-slc5a2 | N/A | Shi et al., 2017 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
familial renal glucosuria | Alliance | Renal glucosuria | 233100 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Sodium/glucose symporter superfamily | Sodium/solute symporter | Sodium/solute symporter, conserved site |
---|---|---|---|---|---|
UniProtKB:Q6NWD8 | InterPro | 662 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
slc5a2-201
(1)
|
Ensembl | 2,334 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-229D23 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85792 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212926 (1) | 2353 nt | ||
Genomic | GenBank:CR749778 (2) | 41352 nt | ||
Polypeptide | UniProtKB:Q6NWD8 (1) | 662 aa |
- Li, X., Schmöhl, F., Qi, H., Bennewitz, K., Tabler, C.T., Poschet, G., Hell, R., Volk, N., Poth, T., Hausser, I., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2020) Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. iScience. 23:101763
- Sander, V., Salleh, L., Naylor, R.W., Schierding, W., Sontam, D.M., O'Sullivan, J.M., Davidson, A.J. (2019) Transcriptional profiling of the zebrafish proximal tubule. American journal of physiology. Renal physiology. 317(2):F478-F488
- Shi, X., Verma, S., Yun, J., Brand-Arzamendi, K., Singh, K.K., Liu, X., Garg, A., Quan, A., Wen, X.Y. (2017) Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?. Molecular and cellular biochemistry. 433(1-2):97-102
- Barat, A., Sahoo, P.K., Kumar, R., Pande, V. (2016) Solute Carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 200:54-61
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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