Gene
sfpq
- ID
- ZDB-GENE-040426-2452
- Name
- splicing factor proline/glutamine-rich
- Symbol
- sfpq Nomenclature History
- Previous Names
-
- hm:zeh0027
- wis (1)
- wu:fa11h12
- wu:fd10f03
- zgc:85935
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within central nervous system development; negative regulation of axon regeneration; and regulation of mRNA processing. Located in neuron projection and nucleus. Is expressed in brain; eye; gut; heart; and muscle cell. Orthologous to human SFPQ (splicing factor proline and glutamine rich).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85935 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1779Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| kg41 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| m427 | unknown | Unknown | Unknown | ENU | |
| sa667 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17716 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa29250 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36893 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tr241 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-sfpq | N/A | (2) |
| MO2-sfpq | N/A | Elsaeidi et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NOPS | Nucleotide-binding alpha-beta plait domain superfamily | PSF, NOPS domain | PSF, RNA recognition motif 1 | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NUU2 | InterPro | 619 | ||||||
| UniProtKB:A0A8M1PEX4 | InterPro | 638 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-1N7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-246P9 | ZFIN Curated Data | |
| Encodes | EST | fa11h12 | ||
| Encodes | EST | fd10f03 | ZFIN Curated Data | |
| Encodes | EST | zeh0027 | ||
| Encodes | cDNA | MGC:85935 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213278 (1) | 2428 nt | ||
| Genomic | GenBank:BX957260 (2) | 188873 nt | ||
| Polypeptide | UniProtKB:A0A8M1PEX4 (1) | 638 aa |
- Taylor, R., Hamid, F., Fielding, T., Gordon, P.M., Maloney, M., Makeyev, E.V., Houart, C. (2022) Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Nature communications. 13:69946994
- Gordon, P.M., Hamid, F., Makeyev, E.V., Houart, C. (2021) A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons. Nature communications. 12:1918
- Sorrells, S., Nik, S., Casey, M., Cameron, R.C., Truong, H., Toruno, C., Gulfo, M., Lowe, A., Jette, C., Stewart, R.A., Bowman, T.V. (2018) Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Disease models & mechanisms. 11(2)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Despic, V., Dejung, M., Gu, M., Krishnan, J., Zhang, J., Herzel, L., Straube, K., Gerstein, M.B., Butter, F., Neugebauer, K.M. (2017) Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome research. 27(7):1184-1194
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Elsaeidi, F., Bemben, M.A., Zhao, X.F., and Goldman, D. (2014) Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(7):2632-2644
- Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618
- Lowery, L.A., De Rienzo, G., Gutzman, J.H., and Sive, H. (2009) Characterization and Classification of Zebrafish Brain Morphology Mutants. The Anatomical record. 292(1):94-106
- Lowery, L.A., Rubin, J., and Sive, H. (2007) whitesnake/sfpq is required for cell survival and neuronal development in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(5):1347-1357
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