Gene

leo1

ID
ZDB-GENE-040426-2435
Name
LEO1 homolog, Paf1/RNA polymerase II complex component
Symbol
leo1 Nomenclature History
Previous Names
  • zgc:77374
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; glial cell differentiation; and xanthophore differentiation. Located in nucleus. Part of Cdc73/Paf1 complex. Is expressed in brain; eye; immature eye; pharyngeal arch; and somite. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
knu6Allele with one point mutationUnknownPremature StopENU
la1186Allele with one point mutationUnknownPremature StopENU
sa2979Allele with one point mutationUnknownPremature StopENU
sa29073Allele with one point mutationUnknownPremature StopENU
sa43155Allele with one point mutationUnknownPremature StopENU
sa44895Allele with one point mutationUnknownUnknownENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-leo1N/AKim et al., 2012
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Human Disease
Associated With leo1 Human Ortholog
No data available
Associated With leo1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007149 Leo1-like protein
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Domain Details Per Protein
Protein Additional Resources Length Leo1-like protein
UniProtKB:Q6NYV9 InterPro 696
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 18
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA leo1-201 (1) Ensembl 2,284 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-7C4ZFIN Curated Data
Contained inBACDKEY-14B24ZFIN Curated Data
EncodescDNAMGC:77374ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanLEO115
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseLeo19
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 9 of 9
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