Gene
leo1
- ID
- ZDB-GENE-040426-2435
- Name
- LEO1 homolog, Paf1/RNA polymerase II complex component
- Symbol
- leo1 Nomenclature History
- Previous Names
-
- zgc:77374
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; glial cell differentiation; and xanthophore differentiation. Located in nucleus. Part of Cdc73/Paf1 complex. Is expressed in brain; eye; immature eye; pharyngeal arch; and somite. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77374 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
knu6 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
la1186 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa2979 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa29073 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa43155 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44895 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR007149 | Leo1-like protein |
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Domain Details Per Protein
Protein | Additional Resources | Length | Leo1-like protein |
---|---|---|---|
UniProtKB:Q6NYV9 | InterPro | 696 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-7C4 | ZFIN Curated Data | |
Contained in | BAC | DKEY-14B24 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77374 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_207067 (1) | 2323 nt | ||
Genomic | GenBank:CR848839 (2) | 101830 nt | ||
Polypeptide | UniProtKB:Q6NYV9 (1) | 696 aa |
- Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
- Sullivan, C., Lage, C.R., Yoder, J.A., Postlethwait, J.H., Kim, C.H. (2017) Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. PLoS One. 12:e0179517
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Rasmussen, J.P., Sack, G.S., Martin, S.M., Sagasti, A. (2015) Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:559-70
- Kim, S., Kim, J.D., Chung, A.Y., Kim, H.S., Kim, Y.S., Kim, M.J., Koun, S., Lee, Y.M., Rhee, M., Park, H.C., and Huh, T.L. (2012) Antagonistic Regulation of PAF1C and p-TEFb Is Required for Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(24):8201-8207
- Villegas, R., Martin, S.M., O'Donnell, K., Carrillo, S., Sagasti, A., and Allende, M.L. (2012) Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types. Neural Development. 7(1):19
- Langenbacher, A.D., Nguyen, C.T., Cavanaugh, A.M., Huang, J., Lu, F., and Chen, J.N. (2011) The PAF1 complex differentially regulates cardiomyocyte specification. Developmental Biology. 353(1):19-28
- Nguyen, C.T., Langenbacher, A., Hsieh, M., and Chen, J.N. (2010) The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish. Developmental Biology. 341(1):167-175
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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