Gene
atf4a
- ID
- ZDB-GENE-040426-2340
- Name
- activating transcription factor 4a
- Symbol
- atf4a Nomenclature History
- Previous Names
-
- atf4
- atf4b1
- wu:fj01c08 (1)
- wu:fk30b04
- zgc:85951
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including intracellular signal transduction; lens fiber cell morphogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription and rhythmic process. Predicted to be part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Predicted to be active in nucleus. Is expressed in several structures, including eye; hindbrain; liver; muscle; and trunk. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85951 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q6NW59 | InterPro | 339 | ||
| UniProtKB:A0A8M2BJE3 | InterPro | 338 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available