Gene
wnt16
- ID
- ZDB-GENE-040426-2330
- Name
- wingless-type MMTV integration site family, member 16
- Symbol
- wnt16 Nomenclature History
- Previous Names
-
- zgc:77293
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including bone regeneration; hematopoietic stem cell differentiation; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; head; neural tube; otic vesicle; and pectoral fin bud. Orthologous to human WNT16 (Wnt family member 16).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77293 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bsl451 | Allele with one delins | Unknown | Unknown | CRISPR | |
| bsl667 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| fh234 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh235 | Allele with one point mutation | Unknown | Unknown | ENU | |
| w1001 | Allele with one delins | Unknown | Unknown | CRISPR | |
| w1008 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| w1009 | Allele with one delins | Unknown | Unknown | CRISPR | |
| w1012 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| wnt16_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| zf3561 | Allele with multiple variants | Unknown | Unknown | CRISPR |
1 - 10 of 10
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wnt16 | (2) | |
| CRISPR2-wnt16 | (2) | |
| CRISPR3-wnt16 | Qu et al., 2021 | |
| CRISPR4-wnt16 | Qu et al., 2021 | |
| CRISPR5-wnt16 | (4) | |
| CRISPR6-wnt16 | (2) | |
| MO1-wnt16 | N/A | (3) |
| MO2-wnt16 | N/A | (6) |
1 - 8 of 8
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt | Wnt-16 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:A5WVL3 | InterPro | 356 | ||||
| UniProtKB:A0A2R8S090 | InterPro | 239 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-129N6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77293 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100046 (1) | 1183 nt | ||
| Genomic | GenBank:CR925699 (1) | 150030 nt | ||
| Polypeptide | UniProtKB:A5WVL3 (1) | 356 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Diamond, K.M., Burtner, A.E., Siddiqui, D., Alvarado, K., Leake, S., Rolfe, S., Zhang, C., Kwon, R.Y., Maga, A.M. (2023) Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases. Journal of anatomy. 243(1):66-77
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Wada, Y., Tsukatani, H., Kuroda, C., Miyazaki, Y., Otoshi, M., Kobayashi, I. (2022) Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish. Development (Cambridge, England). 149(7)
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- McGowan, L.M., Kague, E., Vorster, A., Newham, E., Cross, S., Hammond, C.L. (2021) Wnt16 Elicits a Protective Effect Against Fractures and Supports Bone Repair in Zebrafish. JBMR plus. 5:e10461
- Qu, X., Liao, M., Liu, W., Cai, Y., Yi, Q., Long, J., Tan, L., Deng, Y., Deng, H., Chen, X. (2021) Loss of Wnt16 Leads to Skeletal Deformities and Downregulation of Bone Developmental Pathway in Zebrafish. International Journal of Molecular Sciences. 22(13):
- Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008
- Brunt, L.H., Begg, K., Kague, E., Cross, S., Hammond, C.L. (2017) Wnt signalling controls the response to mechanical loading during Zebrafish joint development. Development (Cambridge, England). 144(15):2798-2809
- Genthe, J.R., Clements, W.K. (2017) R-spondin-1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways. Development (Cambridge, England). 144(4):590-600
1 - 10 of 30
Show