Gene

gnb3b

ID
ZDB-GENE-040426-2280
Name
guanine nucleotide binding protein (G protein), beta polypeptide 3b
Symbol
gnb3b Nomenclature History
Previous Names
  • gnb3
  • wu:fk54b04
  • zgc:73058 (1)
  • zgc:77780
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in epiphysis; eye; pineal complex; retina; and retinal cone cell. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
re22Allele with one deletionUnknownUnknownCRISPR
sa23424Allele with one point mutationUnknownPremature StopENU
sa25084Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-gnb3b (2)
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Human Disease
Associated With gnb3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital stationary night blindness 1H Alliance Night blindness, congenital stationary, type 1H 617024
essential hypertension Alliance {Hypertension, essential, susceptibility to} 145500
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Associated With gnb3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR001632 G-protein, beta subunit
Family IPR016346 Guanine nucleotide-binding protein, beta subunit
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length G-protein, beta subunit G-protein beta WD-40 repeat Guanine nucleotide-binding protein, beta subunit WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6P025 InterPro 338
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gnb3b-201 (1) Ensembl 2,054 nt
mRNA gnb3b-202 (1) Ensembl 1,923 nt
mRNA gnb3b-205 (1) Ensembl 740 nt
ncRNA gnb3b-004 (1) Ensembl 860 nt
ncRNA gnb3b-005 (1) Ensembl 428 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-89B17ZFIN Curated Data
EncodesESTfk54b04ZFIN Curated Data
EncodescDNAMGC:73058
EncodescDNAMGC:77780ZFIN Curated Data
Has ArtifactESTfk54b10
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGNB312
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
MouseGnb36
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 19
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