Gene
mfap4.1
- ID
- ZDB-GENE-040426-2246
- Name
- microfibril associated protein 4, tandem duplicate 1
- Symbol
- mfap4.1 Nomenclature History
- Previous Names
-
- mfap4
- zgc:77076
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be involved in elastic fiber assembly. Predicted to be active in extracellular matrix and extracellular space. Is expressed in endothelial cell; hematopoietic system; macrophage; nervous system; and trunk. Orthologous to human MFAP4 (microfibril associated protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 64 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77076 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19636 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mfap4 | Ong et al., 2020 | |
| CRISPR1-mfap4.1 | Sun et al., 2019 | |
| CRISPR2-mfap4 | Ong et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR050373 | Fibrinogen C-terminal domain-containing protein |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen C-terminal domain-containing protein | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PI90 | InterPro | 242 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mfap4.1-201
(1)
|
Ensembl | 990 nt | ||
| mRNA |
mfap4.1-202
(1)
|
Ensembl | 774 nt | ||
| mRNA |
mfap4.1-203
(1)
|
Ensembl | 853 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mfap4.1:BFP) |
|
| 1 | Thrikawala et al., 2024 | |
| Tg(mfap4.1:Cre-ERT2) |
|
| 1 | (2) | |
| Tg(mfap4.1:EGFP) |
|
| 2 | (7) | |
| Tg(mfap4.1:GAL4VP16) |
|
| 1 | (2) | |
| Tg(mfap4.1:GCaMP6f) |
|
| 1 | Matty et al., 2019 | |
| Tg(mfap4.1:Hsa.GBA1_L444P,myl7:EGFP) |
|
| 1 | Fan et al., 2023 | |
| Tg(mfap4.1:Hsa.GBA1,myl7:EGFP) |
|
| 1 | Fan et al., 2023 | |
| Tg(mfap4.1:Hsa.GBA1_N370S,myl7:EGFP) |
|
| 1 | Fan et al., 2023 | |
| Tg(mfap4.1:iCre-2A-Tomato) |
|
| 1 | (4) | |
| Tg(mfap4.1:lanYFP-CAAX) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-2330D3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77076 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328345 (1) | 1058 nt | ||
| Genomic | GenBank:FP017168 (2) | 46247 nt | ||
| Polypeptide | UniProtKB:A0A8M1PI90 (1) | 242 aa |
- Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787
- Thrikawala, S.U., Anderson, M.H., Rosowski, E.E. (2024) Glucocorticoids Suppress NF-κB-Mediated Neutrophil Control of Aspergillus fumigatus Hyphal Growth. Journal of immunology (Baltimore, Md. : 1950). 213(7):971-987
- Wei, X., Wang, W., Yin, Q., Li, H., Ahmed, A., Ullah, R., Li, W., Jing, L. (2024) In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences. 25(14):
- Xu, Y., Guo, R., Huang, T., Guo, C. (2024) miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway. Cell death discovery. 10:209209
- Yang, X.J., Huang, Z.H., Liu, W., Zhang, W.Q., Huang, Z.B. (2024) Identification and functional characterization of CD209 homologous genes in zebrafish. Yi chuan = Hereditas. 46:947957947-957
- Cacialli, P., Dogan, S., Linnerz, T., Pasche, C., Bertrand, J.Y. (2023) Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. Stem Cell Reports. 18:153415461534-1546
- Fan, J., Hale, V.L., Lelieveld, L.T., Whitworth, L.J., Busch-Nentwich, E.M., Troll, M., Edelstein, P.H., Cox, T.M., Roca, F.J., Aerts, J.M.F.G., Ramakrishnan, L. (2023) Gaucher disease protects against tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2217673120e2217673120
- Ni, Y., Zhang, Y., Zheng, L., Rong, N., Yang, Y., Gong, P., Yang, Y., Siwu, X., Zhang, C., Zhu, L., Fu, Z. (2023) Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota. Life sciences. 324:121699
- Yu, T., Kuang, H., Wu, X., Huang, Y., Wang, J., Wen, Z. (2023) Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia. Science advances. 9:eadf9790
- Zhu, J., Yang, J., Wen, H., Wang, M., Zheng, X., Zhao, J., Sun, X., Yang, P., Mao, Q., Li, Y., Xia, H. (2023) Expression and functional analysis of fam76b in zebrafish. Fish & shellfish immunology. 142:109161
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