Gene

epcam

ID
ZDB-GENE-040426-2209
Name
epithelial cell adhesion molecule
Symbol
epcam Nomenclature History
Previous Names
  • pan-epithelial glycoprotein (1)
  • sb:cb6
  • tacstd
  • wu:fj17g02
  • zgc:110304 (1)
  • zgc:77119
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Acts upstream of or within several processes, including embryonic morphogenesis; liver development; and posterior lateral line neuromast primordium migration. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Is expressed in several structures, including digestive system; integument; pectoral fin bud; pronephros; and sensory system. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy; corneal dystrophy; gelatinous drop-like corneal dystrophy; and hereditary nonpolyposis colorectal cancer type 8. Orthologous to several human genes including EPCAM (epithelial cell adhesion molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 22 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi2151TgTransgenic insertionExon 2UnknownDNA
hi2836TgTransgenic insertionUnknownUnknownDNA
jh79Allele with one deletionUnknownUnknownCRISPR
sa22225Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With epcam Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital diarrhea 5 with tufting enteropathy Alliance Diarrhea 5, with tufting enteropathy, congenital 613217
hereditary nonpolyposis colorectal cancer type 8 Alliance Lynch syndrome 8 613244
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Associated With epcam Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000716 Thyroglobulin type-1
Domain IPR049420 EPCAM/Trop-2, C-terminal
Family IPR043406 Transmembrane glycoprotein EPCAM/Trop-2
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
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Domain Details Per Protein
Protein Additional Resources Length EPCAM/Trop-2, C-terminal Thyroglobulin type-1 Thyroglobulin type-1 superfamily Transmembrane glycoprotein EPCAM/Trop-2
UniProtKB:Q568H0 InterPro 303
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA epcam-201 (1) Ensembl 1,377 nt
ncRNA epcam-002 (1) Ensembl 520 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-105B23ZFIN Curated Data
ContainsSNPrs3728535
    ZFIN Curated Data
    ContainsSNPrs3728536
      ZFIN Curated Data
      EncodesESTcb6ZFIN Curated Data
      EncodesESTfj17g02
      EncodescDNAMGC:77119ZFIN Curated Data
      EncodescDNAMGC:110304ZFIN Curated Data
      Has ArtifactESTfb11f01
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanEPCAM2
      Conserved genome location (synteny) (1)
      Amino acid sequence comparison (2)
      MouseEpcam17
      Amino acid sequence comparison (1)
      Conserved genome location (synteny) (1)
      Citations
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