Gene
epcam
- ID
- ZDB-GENE-040426-2209
- Name
- epithelial cell adhesion molecule
- Symbol
- epcam Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including embryonic morphogenesis; liver development; and posterior lateral line neuromast primordium migration. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Is expressed in several structures, including digestive system; integument; pectoral fin bud; pronephros; and sensory system. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy; corneal dystrophy; gelatinous drop-like corneal dystrophy; and hereditary nonpolyposis colorectal cancer type 8. Orthologous to several human genes including EPCAM (epithelial cell adhesion molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb6 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-epcam | (2) | |
CRISPR2-epcam | Lu et al., 2023 | |
CRISPR3-epcam | Lu et al., 2023 | |
CRISPR4-epcam | Lu et al., 2023 | |
MO1-epcam | N/A | (3) |
MO2-epcam | N/A | (4) |
MO3-epcam | N/A | Melvin et al., 2013 |
1 - 7 of 7
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
congenital diarrhea 5 with tufting enteropathy | Alliance | Diarrhea 5, with tufting enteropathy, congenital | 613217 |
hereditary nonpolyposis colorectal cancer type 8 | Alliance | Lynch syndrome 8 | 613244 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | EPCAM/Trop-2, C-terminal | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily | Transmembrane glycoprotein EPCAM/Trop-2 |
---|---|---|---|---|---|---|
UniProtKB:Q568H0 | InterPro | 303 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-105B23 | ZFIN Curated Data | |
Contains | SNP | rs3728535 | ZFIN Curated Data | |
Contains | SNP | rs3728536 | ZFIN Curated Data | |
Encodes | EST | cb6 | ZFIN Curated Data | |
Encodes | EST | fj17g02 | ||
Encodes | cDNA | MGC:77119 | ZFIN Curated Data | |
Encodes | cDNA | MGC:110304 | ZFIN Curated Data | |
Has Artifact | EST | fb11f01 |
1 - 8 of 8
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001017593 (1) | 1296 nt | ||
Genomic | GenBank:CU570977 (2) | 114114 nt | ||
Polypeptide | UniProtKB:Q568H0 (1) | 303 aa |
- Bufalo, A.J., Vanderbeck, M.M., Schmitt, J., McGraw, H.F. (2024) EpCAM regulates hair cell development and regeneration in the zebrafish lateral line. microPublication. Biology. 2024:
- Lee, S., Memon, A., Chae, S.C., Shin, D., Choi, T.Y. (2024) Epcam regulates intrahepatic bile duct reconstruction in zebrafish, providing a potential model for primary cholangitis model. Biochemical and Biophysical Research Communications. 696:149512149512
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
- Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142
- Ni, Y., Zhang, Y., Zheng, L., Rong, N., Yang, Y., Gong, P., Yang, Y., Siwu, X., Zhang, C., Zhu, L., Fu, Z. (2023) Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota. Life sciences. 324:121699
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Edelman, H.E., McClymont, S.A., Tucker, T.R., Pineda, S., Beer, R.L., McCallion, A.S., Parsons, M.J. (2021) SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer. Human molecular genetics. 30(6):485-499
- Hatzold, J., Wessendorf, H., Pogoda, H.M., Bloch, W., Hammerschmidt, M. (2021) The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Developmental Biology. 476:148-170
1 - 10 of 58
Show