Gene
mmp9
- ID
- ZDB-GENE-040426-2132
- Name
- matrix metallopeptidase 9
- Symbol
- mmp9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Involved in positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including collagen fibril organization; fin regeneration; and positive regulation of granuloma formation. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; female organism; hematopoietic cell; hematopoietic system; and muscle. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 162 figures from 115 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64165 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| el734 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| mi5003 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| mi5004 | Allele with one insertion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| sa12776 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34399 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mmp9 | LeBert et al., 2015 | |
| CRISPR2-mmp9 | LeBert et al., 2015 | |
| CRISPR3-mmp9 | (2) | |
| CRISPR4-mmp9 | (2) | |
| CRISPR5-mmp9 | Giovannone et al., 2019 | |
| CRISPR6-mmp9 | Keatinge et al., 2021 | |
| MO1-mmp9 | N/A | Coyle et al., 2008 |
| MO2-mmp9 | N/A | (2) |
| MO3-mmp9 | N/A | (2) |
| MO4-mmp9 | N/A | (7) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Metaphyseal anadysplasia 2 | 613073 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type II domain | Fibronectin type II domain superfamily | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Kringle-like fold | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T317 | InterPro | 680 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(mmp9:Cre-ERT2,cryaa:EGFP) |
|
| 1 | Ando et al., 2017 | |
| TgBAC(mmp9:EGFP) |
|
| 1 | (4) | |
| TgBAC(mmp9:EGFP-NTR) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-269M15 | ZFIN Curated Data | |
| Contains | SNP | rs3728152 | ZFIN Curated Data | |
| Contains | SNP | rs3728153 | ZFIN Curated Data | |
| Contains | SNP | rs3728154 | ZFIN Curated Data | |
| Encodes | EST | fb02g06 | ZFIN Curated Data | |
| Encodes | EST | fb07b05 | ZFIN Curated Data | |
| Encodes | EST | fi98c09 | ZFIN Curated Data | |
| Encodes | EST | fj05a08 | ||
| Encodes | cDNA | MGC:64165 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175074 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213123 (1) | 2790 nt | ||
| Genomic | GenBank:CR391966 (2) | 105854 nt | ||
| Polypeptide | UniProtKB:Q7T317 (1) | 680 aa |
- Deng, L., Feng, Z., Li, X., Fan, L., Wu, X., Tavakoli, S., Zhu, Y., Ye, H., Wu, K. (2025) Exploring the potential mechanism of B-phycoerythrin on DSS-induced colitis and colitis-associated bone loss based on network pharmacology, molecular docking, and experimental validation. Scientific Reports. 15:54555455
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- Bludau, O., Weber, A., Bosak, V., Kuscha, V., Dietrich, K., Hans, S., Brand, M. (2024) Inflammation is a critical factor for successful regeneration of the adult zebrafish retina in response to diffuse light lesion. Frontiers in cell and developmental biology. 12:13323471332347
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Dirks, R.P., Ordas, A., Jong-Raadsen, S., Brittijn, S.A., Haks, M.C., Henkel, C.V., Oravcova, K., Racz, P.I., Tuinhof-Koelma, N., Korzeniowska Nee Wiweger, M.I., Gillespie, S.H., Meijer, A.H., Ottenhoff, T.H.M., Jansen, H.J., Spaink, H.P. (2024) The Human Pathogen Mycobacterium tuberculosis and the Fish Pathogen Mycobacterium marinum Trigger a Core Set of Late Innate Immune Response Genes in Zebrafish Larvae. Biology. 13(9):
- Fietta, A., Fusco, P., Germano, G., Micheli, S., Sorgato, M., Lucchetta, G., Cimetta, E. (2024) Neuroblastoma-derived hypoxic extracellular vesicles promote metastatic dissemination in a zebrafish model. PLoS One. 19:e0316103e0316103
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Lai, Z.Y., Yang, C.C., Chen, P.H., Chen, W.C., Lai, T.Y., Lu, G.Y., Yang, C.Y., Wang, K.Y., Liu, W.C., Chen, Y.C., Liu, L.Y., Chuang, Y.J. (2024) Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration. Molecular biology reports. 51:604604
- Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A.A., Mialhe, X., Gualda, E., Loza-Alvarez, P., Blanc-Potard, A., Lutfalla, G., Nguyen-Chi, M.E. (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. eLIFE. 13:
- Lin, Y., Li, H., Zheng, S., Han, R., Wu, K., Tang, S., Zhong, X., Chen, J. (2024) Elucidating tobacco smoke-induced craniofacial deformities: Biomarker and MAPK signaling dysregulation unraveled by cross-species multi-omics analysis. Ecotoxicology and environmental safety. 288:117343117343
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