Gene
gadd45ba
- ID
- ZDB-GENE-040426-1971
- Name
- growth arrest and DNA-damage-inducible, beta a
- Symbol
- gadd45ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including regulation of podocyte apoptotic process; response to methylmercury; and somitogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; axis; cleithrum; mesoderm; and nervous system. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb196 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gadd45ba | N/A | (2) |
| MO2-gadd45ba | N/A | Rai et al., 2008 |
| MO3-gadd45ba | N/A | (2) |
| TALEN1-gadd45ba | Thomas et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Growth arrest and DNA damage-inducible protein GADD45 | Ribosomal protein eL30-like superfamily | Ribosomal protein eL8/eL30/eS12/Gadd45 |
|---|---|---|---|---|---|
| UniProtKB:Q6PC51 | InterPro | 159 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gadd45ba-201
(1)
|
Ensembl | 1,295 nt | ||
| ncRNA |
gadd45ba-002
(1)
|
Ensembl | 951 nt | ||
| ncRNA |
gadd45ba-003
(1)
|
Ensembl | 902 nt | ||
| ncRNA |
gadd45ba-004
(1)
|
Ensembl | 917 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-204M7 | ZFIN Curated Data | |
| Encodes | EST | cb196 | ||
| Encodes | EST | fa92d10 | ZFIN Curated Data | |
| Encodes | EST | fa98h12 | ZFIN Curated Data | |
| Encodes | EST | fk65h03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73104 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111973 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192106 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213031 (1) | 1309 nt | ||
| Genomic | GenBank:CU062501 (2) | 103951 nt | ||
| Polypeptide | UniProtKB:Q6PC51 (1) | 159 aa |
- Kong, S., Xiao, Y., Chen, L., Jin, Y., Qiao, R., Xu, K., Xu, L., Wang, H. (2024) Apigenin attenuates cisplatin-induced hair cell damage in the zebrafish lateral line. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 194:115099
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Sun, K., Han, Y., Li, J., Yu, S., Huang, Y., Zhang, Y., Reilly, J., Tu, J., Gao, P., Jia, D., Chen, X., Hu, H., Ren, M., Li, P., Luo, J., Ren, X., Zhang, X., Shu, X., Liu, F., Liu, M., Tang, Z. (2023) The splicing factor DHX38 enables retinal development through safeguarding genome integrity. iScience. 26:108103108103
- Valcarce, D.G., Riesco, M.F., Cuesta-Martín, L., Esteve-Codina, A., Martínez-Vázquez, J.M., Robles, V. (2023) Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny. BMC Biology. 21:7070
- Chatterjee, A., Maity, S., Banerjee, S., Dutta, S., Adhikari, M., Guchhait, R., Biswas, C., De, S., Pramanick, K. (2022) Toxicological impacts of nanopolystyrene on zebrafish oocyte with insight into the mechanism of action: An expression-based analysis. The Science of the total environment. 830:154796
- Li, J., Liu, F., Lv, Y., Sun, K., Zhao, Y., Reilly, J., Zhang, Y., Tu, J., Yu, S., Liu, X., Qin, Y., Huang, Y., Gao, P., Jia, D., Chen, X., Han, Y., Shu, X., Luo, D., Tang, Z., Liu, M. (2021) Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic acids research. 49(4):2027-2043
- Umamaheswari, S., Priyadarshinee, S., Kadirvelu, K., Ramesh, M. (2021) Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish. Chemico-biological interactions. 345:109550
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
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