Gene
ndufa4b
- ID
- ZDB-GENE-040426-1962
- Name
- NDUFA4 mitochondrial complex associated b
- Symbol
- ndufa4b Nomenclature History
- Previous Names
-
- ndufa4
- zgc:73405
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in several structures, including gut; musculature system; nervous system; neural tube; and pericardial region. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 21. Orthologous to human NDUFA4 (NDUFA4 mitochondrial complex associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73405 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012100Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial complex IV deficiency nuclear type 21 | Alliance | ?Mitochondrial complex IV deficiency, nuclear type 21 | 619065 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010530 | NADH-ubiquinone reductase complex 1 MLRQ subunit |
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Domain Details Per Protein
| Protein | Additional Resources | Length | NADH-ubiquinone reductase complex 1 MLRQ subunit |
|---|---|---|---|
| UniProtKB:Q6PBH5 | InterPro | 82 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndufa4-201
(1)
|
Ensembl | 1,403 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-42B22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73405 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213025 (1) | 1100 nt | ||
| Genomic | GenBank:CR392346 (1) | 214585 nt | ||
| Polypeptide | UniProtKB:Q6PBH5 (1) | 82 aa |
- Karampelias, C., Băloiu, B., Rathkolb, B., da Silva-Buttkus, P., Bachar-Wikström, E., Marschall, S., Fuchs, H., Gailus-Durner, V., Chu, L., Hrabě de Angelis, M., Andersson, O. (2024) Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration. Life science alliance. 7(11):
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Dong, N., Bandura, J., Zhang, Z., Wang, Y., Labadie, K., Noel, B., Davison, A., Koene, J.M., Sun, H.S., Coutellec, M.A., Feng, Z.P. (2021) Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis. BMC Genomics. 22:18
- Boyle Anderson, E.A.T., Ho, R.K. (2018) A transcriptomics analysis of the Tbx5 paralogues in zebrafish. PLoS One. 13:e0208766
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- van der Velden, Y.U., Wang, L., Zevenhoven, J., van Rooijen, E., van Lohuizen, M., Giles, R.H., Clevers, H., and Haramis, A.P. (2011) The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(11):4358-4363
- van Rooijen, E., Voest, E.E., Logister, I., Korving, J., Schwerte, T., Schulte-Merker, S., Giles, R.H., and van Eeden, F.J. (2009) Zebrafish mutants in the von Hippel-Lindau (VHL) tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia. Blood. 113(25):6449-6460
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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