Gene
slc30a1a
- ID
- ZDB-GENE-040426-1840
- Name
- solute carrier family 30 member 1a
- Symbol
- slc30a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel inhibitor activity and zinc ion transmembrane transporter activity. Acts upstream of or within melanocyte proliferation and response to zinc ion. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in central nervous system; hatching gland; and yolk syncytial layer. Orthologous to human SLC30A1 (solute carrier family 30 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77589 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Muraina et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc30a1a | (2) | |
| CRISPR2-slc30a1a | (2) | |
| MO1-slc30a1a | N/A | (2) |
| MO2-slc30a1a | N/A | Muraina et al., 2020 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation efflux protein | Cation efflux transmembrane domain superfamily |
|---|---|---|---|---|
| UniProtKB:A0A8M2B789 | InterPro | 501 | ||
| UniProtKB:Q6P3M0 | InterPro | 498 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc30a1a-201
(1)
|
Ensembl | 2,996 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30H14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-249P7 | ||
| Encodes | cDNA | MGC:77589 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200879 (1) | 3007 nt | ||
| Genomic | GenBank:BX248403 (1) | 154669 nt | ||
| Polypeptide | UniProtKB:A0A8M2B789 (1) | 501 aa |
- Secli, V., Di Biagio, C., Martini, A., Michetti, E., Pacello, F., Ammendola, S., Battistoni, A. (2023) Localized Infections with P. aeruginosa Strains Defective in Zinc Uptake Reveal That Zebrafish Embryos Recapitulate Nutritional Immunity Responses of Higher Eukaryotes. International Journal of Molecular Sciences. 24(2):
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Xia, Z., Yang, X., Bi, X., Tong, X., Min, J., Wang, F. (2022) Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish. European journal of cell biology. 101:151272
- Xia, Z., Bi, X., Yang, S., Yang, X., Song, Z., Wei, J., Xu, P., Rink, L., Min, J., Wang, F. (2021) Metal transporter Slc30a1 controls pharyngeal neural crest differentiation via the zinc-Snai2-Jag1 cascade. MedComm. 2:778-797
- Kong, N., Zhao, Q., Liu, C., Li, J., Liu, Z., Gao, L., Wang, L., Song, L. (2020) The involvement of zinc transporters in the zinc accumulation in the Pacific oyster Crassostrea gigas. Gene. 750:144759
- Muraina, I.A., Bury, N.R., Scott, A., Graham, A., Hogstrand, C. (2020) The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 60:126496
- Muraina, I.A., Maret, W., Bury, N.R., Hogstrand, C. (2020) Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a. Biochemical and Biophysical Research Communications. 528(4):698-705
- Wang, C.C., Si, L.F., Guo, S.N., Zheng, J.L. (2019) Negative effects of acute cadmium on stress defense, immunity, and metal homeostasis in liver of zebrafish: The protective role of environmental zinc dpre-exposure. Chemosphere. 222:91-97
- Zhao, L., Tan, J., Li, D., Jiang, L., Li, T., Yang, Y., Wang, G., Shang, Z., Wang, J., Zhou, J. (2019) SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Biochemical and Biophysical Research Communications. 511(4):896-902
- Zhu, Q.L., Li, W.Y., Zheng, J.L. (2018) Life-cycle exposure to cadmium induced compensatory responses towards oxidative stress in the liver of female zebrafish. Chemosphere. 210:949-957
1 - 10 of 25
Show