Gene
tmem88a
- ID
- ZDB-GENE-040426-1808
- Name
- transmembrane protein 88 a
- Symbol
- tmem88a Nomenclature History
- Previous Names
-
- zgc:77242
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within cardiac muscle cell fate commitment; hemopoiesis; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in blood cell; cardiovascular system; and mesoderm. Orthologous to human TMEM88 (transmembrane protein 88).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77242 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tmem88a | Capon et al., 2017 | |
| CRISPR2-tmem88a | Capon et al., 2017 | |
| CRISPR3-tmem88a | (2) | |
| MO1-tmem88a | N/A | (3) |
| MO2-tmem88a | N/A | (2) |
| MO3-tmem88a | N/A | Novikov et al., 2013 |
| MO4-tmem88a | N/A | Novikov et al., 2013 |
| TALEN1-tmem88a | Eve et al., 2017 |
1 - 8 of 8
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR033355 | Transmembrane protein 88 |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Transmembrane protein 88 |
|---|---|---|---|
| UniProtKB:Q6P0G3 | InterPro | 215 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tmem88a-201
(1)
|
Ensembl | 1,301 nt | ||
| mRNA |
tmem88a-202
(1)
|
Ensembl | 1,343 nt | ||
| mRNA |
tmem88a-203
(1)
|
Ensembl | 2,211 nt | ||
| mRNA |
tmem88a-204
(1)
|
Ensembl | 1,648 nt |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237L4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77242 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173934 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173935 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205670 (1) | 1285 nt | ||
| Genomic | GenBank:AL807389 (1) | 143672 nt | ||
| Polypeptide | UniProtKB:Q6P0G3 (1) | 215 aa |
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Liu, J., Yang, L., Lu, Z., Wang, Q. (2023) Tmem88 plays an essential role in pharyngeal pouch progenitor specification by inhibiting Wnt/β-catenin signaling. Life medicine. 2:lnad044lnad044
- Metikala, S., Warkala, M., Casie Chetty, S., Chestnut, B., Rufin Florat, D., Plender, E., Nester, O., Koenig, A.L., Astrof, S., Sumanas, S. (2022) Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Developmental Cell. 57(6):767-782.e6
- Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
- Yu, S.H., Zhu, K.Y., Zhang, F., Wang, J., Yuan, H., Chen, Y., Jin, Y., Dong, M., Wang, L., Jia, X.E., Gao, L., Dong, Z.W., Ren, C.G., Chen, L.T., Huang, Q.H., Deng, M., Zon, L.I., Zhou, Y., Zhu, J., Xu, P.F., Liu, T.X. (2018) The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochimica et biophysica acta. 1861(2):106-116
- Capon, S.J., Baillie, G.J., Bower, N.I., da Silva, J.A., Paterson, S., Hogan, B.M., Simons, C., Smith, K.A. (2017) Utilising polymorphisms to achieve allele-specific genome editing in zebrafish. Biology Open. 6(1):125-131
- Eve, A.M., Place, E.S., Smith, J.C. (2017) Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes. PLoS One. 12:e0172227
- Quillien, A., Abdalla, M., Yu, J., Ou, J., Zhu, L.J., Lawson, N.D. (2017) Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq. Cell Reports. 20:709-720
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K., Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A., Zon, L.I. (2015) Chamber identity programs drive early functional partitioning of the heart. Nature communications. 6:8146
1 - 10 of 19
Show