Gene
dnm1l
- ID
- ZDB-GENE-040426-1556
- Name
- dynamin 1-like
- Symbol
- dnm1l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including intracellular distribution of mitochondria; mitochondrion organization; and peroxisome fission. Predicted to act upstream of or within rhythmic process. Predicted to be located in cytosol; mitochondrial outer membrane; and peroxisome. Predicted to be active in membrane; microtubule; and mitochondrion. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| encephalopathy due to defective mitochondrial and peroxisomal fission 1 | Alliance | Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 | 614388 |
| optic atrophy 5 | Alliance | Optic atrophy 5 | 610708 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynamin | Dynamin, GTPase domain | Dynamin GTPase effector | Dynamin, GTPase region, conserved site | Dynamin, N-terminal | Dynamin stalk domain | Dynamin-type guanine nucleotide-binding (G) domain | GTPase effector domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BA46 | InterPro | 703 | |||||||||
| UniProtKB:Q7SXN5 | InterPro | 691 | |||||||||
| UniProtKB:A0A140LH30 | InterPro | 715 | |||||||||
| UniProtKB:A0A8M2BAD6 | InterPro | 727 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(isl2b:TagBFP-dndnm1l_K38A) |
|
| 1 | Beckers et al., 2023 | |
| Tg(isl2b:TagBFP-dnm1l) |
|
| 1 | Beckers et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-206M15 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7139392 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66163 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200922 (1) | 2455 nt | ||
| Genomic | GenBank:BX928758 (2) | 90241 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAD6 (1) | 727 aa |
- Aranda-Martínez, P., Sayed, R.K.A., Fernández-Martínez, J., Ramírez-Casas, Y., Yang, Y., Escames, G., Acuña-Castroviejo, D. (2024) Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. International Journal of Molecular Sciences. 25(11):
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Ruparelia, A.A., Montandon, M., Merriner, J., Huang, C., Wong, S.F.L., Sonntag, C., Hardee, J.P., Lynch, G.S., Miles, L.B., Siegel, A., Hall, T.E., Schittenhelm, R.B., Currie, P.D. (2024) Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP. JCI insight. 9(8):
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Xiao, G., Li, X., Yang, H., Zhang, R., Huang, J., Tian, Y., Nie, M., Sun, X. (2024) mTOR mutation disrupts larval zebrafish tail fin regeneration via regulating proliferation of blastema cells and mitochondrial functions. Journal of orthopaedic surgery and research. 19:321321
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- Beckers, A., Masin, L., Van Dyck, A., Bergmans, S., Vanhunsel, S., Zhang, A., Verreet, T., Poulain, F.E., Farrow, K., Moons, L. (2023) Optic nerve injury-induced regeneration in the adult zebrafish is accompanied by spatiotemporal changes in mitochondrial dynamics. Neural regeneration research. 18:219-225
- Wen, W., Guo, C., Chen, Z., Yang, D., Zhu, D., Jing, Q., Zheng, L., Sun, C., Tang, C. (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. PLoS One. 18:e0294700e0294700
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
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