Gene
slc5a1
- ID
- ZDB-GENE-040426-1524
- Name
- solute carrier family 5 member 1
- Symbol
- slc5a1 Nomenclature History
- Previous Names
-
- SGLT1 (1)
- zgc:66074
- zgc:85782
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable D-glucose:sodium symporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in digestive system and pronephric duct. Human ortholog(s) of this gene implicated in glucose-galactose malabsorption. Orthologous to several human genes including SLC5A1 (solute carrier family 5 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85782 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12741 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13706 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31773 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41620 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41621 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41622 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glucose-galactose malabsorption | Alliance | Glucose/galactose malabsorption | 606824 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sodium/glucose symporter superfamily | Sodium/solute symporter | Sodium/solute symporter, conserved site |
|---|---|---|---|---|---|
| UniProtKB:Q6NWE6 | InterPro | 658 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc5a1-202
(1)
|
Ensembl | 2,655 nt | ||
| ncRNA |
slc5a1-002
(1)
|
Ensembl | 941 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-106L3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66074 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85782 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200681 (1) | 2700 nt | ||
| Genomic | GenBank:BX324123 (1) | 158061 nt | ||
| Polypeptide | UniProtKB:Q6NWE6 (1) | 658 aa |
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727
- Blanco, A.M., Bertucci, J.I., Unniappan, S. (2020) FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Scientific Reports. 10:6993
- Li, X., Schmöhl, F., Qi, H., Bennewitz, K., Tabler, C.T., Poschet, G., Hell, R., Volk, N., Poth, T., Hausser, I., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2020) Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. iScience. 23:101763
- Rajeswari, J.J., Blanco, A.M., Unniappan, S. (2020) Phoenixin-20 (PNX-20) Suppresses Food Intake, Modulates Glucoregulatory Enzymes, and Enhances Glycolysis in Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 318(5):R917-R928
- Qian, L., Zhang, J., Chen, X., Qi, S., Wu, P., Wang, C., Wang, C. (2019) Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. Environmental pollution (Barking, Essex : 1987). 247:775-782
- Willi, R.A., Faltermann, S., Hettich, T., Fent, K. (2017) Active glucocorticoids have a range of important adverse developmental and physiological effects on developing zebrafish embryos. Environmental science & technology. 52(2):877-885
- Barat, A., Sahoo, P.K., Kumar, R., Pande, V. (2016) Solute Carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 200:54-61
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