Gene
slc2a12
- ID
- ZDB-GENE-040426-1513
- Name
- solute carrier family 2 member 12
- Symbol
- slc2a12 Nomenclature History
- Previous Names
-
- zgc:66027
- zgc:85776
- zglut12 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable D-glucose transmembrane transporter activity. Acts upstream of or within glucose import in response to insulin stimulus; heart contraction; and heart valve morphogenesis. Predicted to be located in endomembrane system; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including alar plate midbrain region; immature eye; muscle; nervous system; and pleuroperitoneal region. Orthologous to human SLC2A12 (solute carrier family 2 member 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66027 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Jiménez-Amilburu et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022653Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12204 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12272 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24373 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37756 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-slc2a12 | N/A | Jiménez-Amilburu et al., 2015 |
| MO2-slc2a12 | N/A | Jiménez-Amilburu et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR005829 | Sugar transporter, conserved site |
| Domain | IPR020846 | Major facilitator superfamily domain |
| Family | IPR003663 | Sugar/inositol transporter |
| Family | IPR005828 | Major facilitator, sugar transporter-like |
| Family | IPR050820 | Major Facilitator Superfamily Sugar Transporter |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator, sugar transporter-like | Major facilitator superfamily domain | Major Facilitator Superfamily Sugar Transporter | MFS transporter superfamily | Sugar/inositol transporter | Sugar transporter, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NWF1 | InterPro | 610 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc2a12-201
(1)
|
Ensembl | 2,401 nt | ||
| mRNA |
slc2a12-202
(1)
|
Ensembl | 840 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-161P7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66027 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85776 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200538 (1) | 2386 nt | ||
| Genomic | GenBank:BX927365 (1) | 229608 nt | ||
| Polypeptide | UniProtKB:Q6NWF1 (1) | 610 aa |
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677
- Zhao, T., Ye, Z., Liu, Y., Lin, H., Li, S., Zhang, Y. (2022) Mutation of spexin2 promotes feeding, somatic growth, adiposity and insulin resistance in zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 322(5):R454-R465
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Wang, Q., Luo, C., Lu, G., Chen, Z. (2020) Effect of AMPK-p53-klf2a Pathway in Hyperglycemia-induced Cardiac Remodeling in Adult Zebrafish. Journal of diabetes investigation. 12(3):320-333
- Houbrechts, A.M., Beckers, A., Vancamp, P., Sergeys, J., Gysemans, C., Mathieu, C., Darras, V.M. (2019) Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish. Endocrinology. 160(11):2759-2772
- Dalmolin, C., Almeida, D.V., Figueiredo, M.A., Marins, L.F. (2018) Expression profile of glucose transport-related genes under chronic and acute exposure to growth hormone in zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 221:1-6
- Li, Y.C., Zhang, M.Q., Zhang, J.P. (2018) Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish. Frontiers in cellular and infection microbiology. 8:109
- Chatzopoulou, A., Schoonheim, P.J., Torraca, V., Meijer, A.H., Spaink, H.P., Schaaf, M.J. (2017) Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Molecular and Cellular Endocrinology. 447:61-70
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