Gene
cdkal1
- ID
- ZDB-GENE-040426-1443
- Name
- CDK5 regulatory subunit associated protein 1-like 1
- Symbol
- cdkal1 Nomenclature History
- Previous Names
-
- zgc:65864
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in diabetes mellitus; diabetic retinopathy; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65864 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012999Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa36008 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42636 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cdkal1 | N/A | O'Hare et al., 2016 |
| MO2-cdkal1 | N/A | O'Hare et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Elp3/MiaA/NifB-like, radical SAM core domain | Methylthiotransferase | Methylthiotransferase, conserved site | Methylthiotransferase, N-terminal | Methylthiotransferase, N-terminal domain superfamily | MiaB-like tRNA modifying enzyme, archaea/eukaryota | Radical SAM | Radical SAM, alpha/beta horseshoe | TRAM domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PG34 | InterPro | 547 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdkal1-201
(1)
|
Ensembl | 1,032 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(EPV.Tp1:cdkal1,myl7:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:65864 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200627 (1) | 2090 nt | ||
| Genomic | GenBank:CABZ01113119 (1) | 15293 nt | ||
| Polypeptide | UniProtKB:Q6PG34 (1) | 547 aa |