Gene
slc18a3b
- ID
- ZDB-GENE-040426-1410
- Name
- solute carrier family 18 member 3b
- Symbol
- slc18a3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable acetylcholine transmembrane transporter activity. Predicted to be involved in chemical synaptic transmission. Predicted to act upstream of or within transmembrane transport and xenobiotic transport. Predicted to be located in membrane. Predicted to be part of AP-1 adaptor complex and AP-2 adaptor complex. Predicted to be active in terminal bouton. Is expressed in central nervous system and spinal cord neural tube. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myasthenic syndrome 21 | Alliance | Myasthenic syndrome, congenital, 21, presynaptic | 617239 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020846 | Major facilitator superfamily domain |
| Family | IPR004734 | Multidrug resistance protein |
| Family | IPR011701 | Major facilitator superfamily |
| Family | IPR050930 | Major Facilitator Superfamily Vesicular Transporter |
| Homologous_superfamily | IPR036259 | MFS transporter superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator superfamily | Major facilitator superfamily domain | Major Facilitator Superfamily Vesicular Transporter | MFS transporter superfamily | Multidrug resistance protein |
|---|---|---|---|---|---|---|---|
| UniProtKB:P59845 | InterPro | 493 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc18a3b-201
(1)
|
Ensembl | 1,296 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:64220 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201107 (1) | 1744 nt | ||
| Genomic | GenBank:CABZ01112647 (1) | |||
| Polypeptide | UniProtKB:P59845 (1) | 493 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Ncube, D., Tallafuss, A., Serafin, J., Bruckner, J., Farnsworth, D.R., Miller, A.C., Eisen, J.S., Washbourne, P. (2022) A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior. BMC Genomics. 23:675
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Liu, S., Yu, M., Xie, X., Ru, Y., Ru, S. (2020) Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Chemosphere. 253:126635
- Rima, M., Lattouf, Y, Abi Younes, M., Bullier, E., Legendre, P., Mangin, J.M., Hong, E. (2020) Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific Reports. 10(1):15338
- Henriques, P.M., Rahman, N., Jackson, S.E., Bianco, I.H. (2019) Nucleus Isthmi Is Required to Sustain Target Pursuit during Visually Guided Prey-Catching. Current biology : CB. 29(11):1771-1786.e5
- Lekk, I., Duboc, V., Faro, A., Nicolaou, S., Blader, P., Wilson, S.W. (2019) Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry. eLIFE. 8:
- Saha, M., Rizzo, S.A., Ramanathan, M., Hightower, R.M., Santostefano, K.E., Terada, N., Finkel, R.S., Berg, J.S., Chahin, N., Pacak, C.A., Wagner, R.E., Alexander, M.S., Draper, I., Kang, P.B. (2019) Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy. Human molecular genetics. 28:2365-2377
- Falisse, E., Ducos, B., Stockwell, P.A., Morison, I.M., Chatterjee, A., Silvestre, F. (2018) DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Environmental pollution (Barking, Essex : 1987). 243:1867-1877
- Schredelseker, T., Driever, W. (2018) Bsx controls pineal complex development. Development (Cambridge, England). 145(13):
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