Gene
ucp3
- ID
- ZDB-GENE-040426-1317
- Name
- uncoupling protein 3
- Symbol
- ucp3 Nomenclature History
- Previous Names
-
- ucp2l
- zgc:63967
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to act upstream of or within transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including brain; eye; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63967 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa41711 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitochondrial carrier domain superfamily | Mitochondrial carrier protein | Mitochondrial Metabolite Transporter | Mitochondrial substrate/solute carrier |
|---|---|---|---|---|---|---|
| UniProtKB:A8KC25 | InterPro | 309 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-176G13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63967 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174528 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200353 (1) | 1666 nt | ||
| Genomic | GenBank:BX649477 (1) | 148317 nt | ||
| Polypeptide | UniProtKB:A8KC25 (1) | 309 aa |
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770
- Wang, Y., Teng, M., Wang, D., Yan, J., Miao, J., Zhou, Z., Zhu, W. (2017) Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Environmental pollution (Barking, Essex : 1987). 229:264-271
- Huang, G., Zhang, F., Ye, Q., Wang, H. (2016) The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Autophagy. 12(8):1292-309
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sagi, D., and Kim, S.K. (2012) An Engineering Approach to Extending Lifespan in C. elegans. PLoS Genetics. 8(6):e1002780
- Tseng, Y.C., Chen, R.D., Lucassen, M., Schmidt, M.M., Dringen, R., Abele, D., and Hwang, P.P. (2011) Exploring Uncoupling Proteins and Antioxidant Mechanisms under Acute Cold Exposure in Brains of Fish. PLoS One. 6(3):e18180
- Saito, S., Saito, C.T., and Shingai, R. (2008) Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals. Gene. 408(1-2):37-44
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