Gene
msi2b
- ID
- ZDB-GENE-040426-1268
- Name
- musashi RNA-binding protein 2b
- Symbol
- msi2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within olfactory bulb development. Predicted to be active in cytoplasm. Is expressed in nervous system and otic vesicle. Orthologous to human MSI2 (musashi RNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hochgreb-Hägele et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ct57aGt | Transgenic insertion | Unknown | Unknown | DNA | |
la012722Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la019312Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la019313Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la019315Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-msi2b | N/A | Hochgreb-Hägele et al., 2014 |
MO2-msi2b | N/A | Hochgreb-Hägele et al., 2014 |
TALEN1-msi2b | Hochgreb-Hägele et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000504 | RNA recognition motif domain |
Domain | IPR034126 | RNA-binding protein Musashi homologue, RNA recognition motif 2 |
Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA-binding protein Musashi homologue, RNA recognition motif 2 | RNA recognition motif domain |
---|---|---|---|---|---|---|
UniProtKB:A0A8M9QBW9 | InterPro | 363 | ||||
UniProtKB:A0A8M2B414 | InterPro | 307 | ||||
UniProtKB:Q7SXT6 | InterPro | 408 | ||||
UniProtKB:A0A8M2B3X4 | InterPro | 329 | ||||
UniProtKB:A0A8M2B4J9 | InterPro | 389 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-197C11 | ZFIN Curated Data | |
Contained in | BAC | CH211-209M20 | ZFIN Curated Data | |
Contained in | BAC | DKEY-181C10 | ZFIN Curated Data | |
Contained in | BAC | RP71-9L22 | ZFIN Curated Data | |
Encodes | cDNA | MGC:63812 | ZFIN Curated Data | |
Encodes | cDNA | MGC:174035 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201109 (1) | 1852 nt | ||
Genomic | GenBank:BX000438 (1) | 195087 nt | ||
Polypeptide | UniProtKB:A0A8M3AIG3 (1) | 408 aa |
- Picton, L.D., Bertuzzi, M., Pallucchi, I., Fontanel, P., Dahlberg, E., Björnfors, E.R., Iacoviello, F., Shearing, P.R., El Manira, A. (2021) A spinal organ of proprioception for integrated motor action feedback. Neuron. 109(7):1188-1201.e7
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Nakayama, Y., Inomata, C., Yuikawa, T., Tsuda, S., Yamasu, K. (2017) Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Developmental Biology. 430(1):237-248
- Xie, Y., Kaufmann, D., Moulton, M.J., Panahi, S., Gaynes, J.A., Watters, H.N., Zhou, D., Xue, H.H., Fung, C.M., Levine, E.M., Letsou, A., Brennan, K.C., Dorsky, R.I. (2017) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biology. 15:e2002257
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hochgreb-Hägele, T., Koo, D.E., Das, N.M., and Bronner, M.E. (2014) Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants. Stem cells (Dayton, Ohio). 32(2):558-571
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
- McGrail, M., Hatler, J.M., Kuang, X., Liao, H.K., Nannapaneni, K., Noack Watt, K.E., Uhl, J.D., Largaespada, D.A., Vollbrecht, E., Scheetz, T.E., Dupuy, A.J., Hostetter, J.M., and Essner, J.J. (2011) Somatic mutagenesis with a sleeping beauty transposon system leads to solid tumor formation in zebrafish. PLoS One. 6(4):e18826
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