Gene
mnx2b
- ID
- ZDB-GENE-040415-2
- Name
- motor neuron and pancreas homeobox 2b
- Symbol
- mnx2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity. Acts upstream of or within spinal cord motor neuron cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including endodermal cell; lateral mesoderm; motor neurons; spinal cord; and spinal cord neural tube.
- Genome Resources
- Note
-
The name of this gene was changed from hlxb9lb to mnx2b to more accurately reflect its relationship to the MNX family of genes.
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from See et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mnx2b | Sun et al., 2019 | |
| MO1-mnx2b | N/A | (4) |
| MO2-mnx2b | N/A | See et al., 2014 |
| MO3-mnx2b | N/A | See et al., 2014 |
| MO4-mnx2b | N/A | Ott et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein MNX1/Ceh-12 | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1RCJ6 | InterPro | 328 | |||||
| UniProtKB:A2CEW5 | InterPro | 320 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(mnx2b:GAL4FF) |
|
| 1 | (10) | |
| TgBAC(mnx2b-hsp70l:EGFP-tardbpb) |
|
| 1 | (2) | |
| TgBAC(mnx2b-hsp70l:GAL4FF) |
|
| 1 | (2) | |
| TgBAC(mnx2b-hsp70l:mRFP1-Hsa.TARDBP_A315T-Ath.Cry2) |
|
| 1 | Asakawa et al., 2020 | |
| TgBAC(mnx2b-hsp70l:mRFP1-Hsa.TARDBP-Ath.Cry2) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-172N16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194669 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328358 (1) | 1152 nt | ||
| Genomic | GenBank:CR762428 (1) | 140219 nt | ||
| Polypeptide | UniProtKB:F1RCJ6 (1) | 328 aa |
No data available
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Asakawa, K., Handa, H., Kawakami, K. (2022) Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae. Journal of visualized experiments : JoVE. (180):
- Asakawa, K., Handa, H., Kawakami, K. (2020) Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nature communications. 11:1004
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Asakawa, K., Kawakami, K. (2018) Protocadherin-Mediated Cell Repulsion Controls the Central Topography and Efferent Projections of the Abducens Nucleus. Cell Reports. 24:1562-1572
- Gong, J., Wang, X., Zhu, C., Dong, X., Zhang, Q., Wang, X., Duan, X., Qian, F., Shi, Y., Gao, Y., Zhao, Q., Chai, R., Liu, D. (2017) Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in molecular neuroscience. 10:274
- Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D. (2016) Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm. Developmental Biology. 411(1):101-14
- Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K., Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A., Zon, L.I. (2015) Chamber identity programs drive early functional partitioning of the heart. Nature communications. 6:8146
- See, K., Yadav, P., Giegerich, M., Cheong, P.S., Graf, M., Vyas, H., Lee, S.G., Mathavan, S., Fischer, U., Sendtner, M., and Winkler, C. (2014) SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Human molecular genetics. 23(7):1754-70
- Van Ryswyk, L., Simonson, L., and Eisen, J.S. (2014) The role of inab in axon morphology of an identified zebrafish motoneuron. PLoS One. 9(2):e88631
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