Gene
tlr7
- ID
- ZDB-GENE-040219-11
- Name
- toll-like receptor 7
- Symbol
- tlr7 Nomenclature History
- Previous Names
-
- TLR7A (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable pattern recognition receptor activity. Predicted to be involved in several processes, including canonical NF-kappaB signal transduction; positive regulation of interleukin-6 production; and toll-like receptor signaling pathway. Predicted to act upstream of or within inflammatory response; innate immune response; and signal transduction. Predicted to be located in endosome and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tlr7 | Esancy et al., 2018 | |
| CRISPR2-tlr7 | Peña et al., 2021 | |
| MO1-tlr7 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| X-Linked immunodeficiency 74 | Alliance | Immunodeficiency 74, COVID19-related, X-linked | 301051 |
| Systemic lupus erythematosus 17 | 301080 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QKF3 | InterPro | 1036 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available